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  4. RPN1 Recombinant Monoclonal Antibody

RPN1 Recombinant Monoclonal Antibody

  • 中文名稱：
    RPN1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA170115A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of ribophorin I expression in HT-1080 cells using ribophorin I antibody. Green, isotype control; red, ribophorin I.
    • Immunocytochemical staining of HT-1080 cells with Ribophorin I antibody. Nuclei were stained blue with DAPI; Ribophorin I was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using ribophorin I antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ribophorin I antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Ribophorin I; OST1; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 1; Oligosaccharyltransferase Complex Subunit (Non-Catalytic); Ribophorin-1; RPN-I; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 67 KDa Subunit; Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase 67 KDa Subunit; Oligosaccharyltransferase 1 Homolog (S. Cerevisiae); Oligosaccharyltransferase 1 Homolog; EC 2.4.1.119; RBPH1
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human RPN1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    25E3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
  • 基因功能參考文獻(xiàn)：
    1. These results clearly demonstrate that the association of malectin with ribophorin I is required to capture misfolded alpha1-antitrypsin and direct them to the degradation pathway. PMID: 25451265
    2. Data indicate that malectin functions by forming a complex with ribophorin I. PMID: 22988243
    3. ribophorin I can regulate the delivery of precursor proteins to the OST complex by capturing substrates and presenting them to the catalytic core. PMID: 18607003
  • 亞細(xì)胞定位：
    Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • 蛋白家族：
    OST1 family
  • 組織特異性：
    Expressed in all tissues tested.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10381

    OMIM: 180470

    KEGG: hsa:6184

    STRING: 9606.ENSP00000296255

    UniGene: Hs.518244