日韩在线视频不卡-日一区二区三区-天堂国产+人+综合+亚洲欧美-精品国产一区二区三区久久狼-国产成人无码18禁午夜福利网址-国产在线拍偷自揄拍精品-九色91丨porny丨丝袜-久久天天躁狠狠躁夜夜av-99蜜桃臀久久久欧美精品-成人一区二区视频-狠狠操人人干-40岁干柴烈火少妇高潮不断-国产福利不卡-伊人98-丰满多毛的陰户视频-日韩一二三四五区-国产专区一线二线三线码-好男人社区影院www-国产精品2019-欧美三级一区

          Your Good Partner in Biology Research

          Phospho-ATRIP (S68) Antibody

          • 中文名稱:
            磷酸化-ATRIP (S68)兔多克隆抗體
          • 貨號:
            CSB-PA060304
          • 規格:
            ¥1090
          • 圖片:
            • Western Blot analysis of NIH-3T3 cells using Phospho-ATRIP (S68) Polyclonal Antibody
          • 其他:

          產品詳情

          • Uniprot No.:
          • 基因名:
            ATRIP
          • 別名:
            AGS1 antibody; ATIP antibody; ATM and Rad3 related interacting protein antibody; ATM and Rad3-related-interacting protein antibody; ATR interacting protein antibody; ATR-interacting protein antibody; Atrip antibody; ATRIP_HUMAN antibody; DKFZp762J2115 antibody; FLJ12343 antibody; MGC20625 antibody; MGC21482 antibody; MGC26740 antibody
          • 宿主:
            Rabbit
          • 反應種屬:
            Human,Mouse,Rat
          • 免疫原:
            Synthesized peptide derived from Human ATRIP around the phosphorylation site of S68.
          • 免疫原種屬:
            Homo sapiens (Human)
          • 標記方式:
            Non-conjugated
          • 抗體亞型:
            IgG
          • 純化方式:
            The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
          • 濃度:
            It differs from different batches. Please contact us to confirm it.
          • 保存緩沖液:
            Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
          • 產品提供形式:
            Liquid
          • 應用范圍:
            WB, ELISA
          • 推薦稀釋比:
            Application Recommended Dilution
            WB 1:500-1:2000
            ELISA 1:40000
          • Protocols:
          • 儲存條件:
            Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
          • 貨期:
            Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
          • 用途:
            For Research Use Only. Not for use in diagnostic or therapeutic procedures.

          產品評價

          靶點詳情

          • 功能:
            Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
          • 基因功能參考文獻:
            1. ATRIP deacetylation by SIRT2 promotes ATR-ATRIP binding to replication protein A-single-stranded DNA to drive ATR activation and thus facilitate recovery from replication stress. PMID: 26854234
            2. ATRIP SUMOylation promotes ATR activation by providing a unique type of protein glue that boosts multiple protein interactions along the ATR pathway PMID: 24990965
            3. Data on crystal structure of BRCA1 binding with phosphopeptides suggest that C-terminal domain of BRCA1 interacts with ATRIP and BAAT1 with preferences for specific side chains; in ATRIP, phospho-Ser239 and Phe242 are the main interacting residues. PMID: 24073851
            4. Data indicate that ATRIP is a direct target gene of HIF-1, and the increased ATRIP then activates the ATR signaling pathway under hypoxia. PMID: 23454212
            5. our analysis exposes an overlapping clinical manifestation between the disorders but allows an expanded spectrum of clinical features for ATR-ATRIP Seckel Syndrome to be defined PMID: 23144622
            6. as an ATR-associated kinase, Nek1 enhances the stability and activity of ATR-ATRIP before DNA damage, priming ATR-ATRIP for a robust DNA damage response PMID: 23345434
            7. ATRIP may function outside the context of the canonical ATR damage signaling pathway during HSV-1 infection to participate in the viral life cycle. PMID: 20861269
            8. data suggest that RPA-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling PMID: 12791985
            9. there are at least two in vitro ATR-ATRIP DNA binding complexes, one which binds DNA with high affinity in an RPA-dependent manner and a second, which binds DNA with lower affinity in an RPA-independent manner PMID: 14724280
            10. Collectively, our results suggest that the ATR-mediated phosphorylation of ATRIP at Ser-68 and -72 is dispensable for the initial response to DNA damage. PMID: 15451423
            11. N-terminal domain of the ATRIP protein contributes to the cell cycle checkpoint by regulating the intranuclear localization of ATR PMID: 15527801
            12. ATRIP is required for ATR accumulation at intranuclear foci induced by DNA damage. PMID: 15743907
            13. ATRIP oligomerization is essential for the function of the ATM and Rad3-related (ATR)-ATRIP complex, which exists in higher order oligomeric states within cells PMID: 16027118
            14. The expression of dimerization-defective ATRIP diminishes the maintenance of replication forks during treatment with DNA replication inhibitors. PMID: 16176973
            15. support the idea of a multistep model for ATR activation that requires separable localization and activation functions of ATRIP PMID: 17339343
            16. a direct physical interaction between BRCA1 and ATRIP is required for the checkpoint function of ATR PMID: 17616665
            17. ATRIP is a CDK2 substrate, and CDK2-dependent phosphorylation of S224 regulates the ability of ATR-ATRIP to promote cell cycle arrest in response to DNA damage PMID: 17638878

            顯示更多

            收起更多

          • 亞細胞定位:
            Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage.
          • 蛋白家族:
            ATRIP family
          • 組織特異性:
            Ubiquitous.
          • 數據庫鏈接:

            HGNC: 33499

            OMIM: 606605

            KEGG: hsa:84126

            STRING: 9606.ENSP00000323099

            UniGene: Hs.694840