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  4. PAK3 Antibody

PAK3 Antibody

  • 中文名稱：
    PAK3兔多克隆抗體
  • 貨號：
    CSB-PA017407LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse lung tissue, Mouse skeletal muscle tissue
      All lanes: PAK3 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 63, 61, 65 kDa
      Observed band size: 63 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA017407LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA017407LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PAK3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PAK3 antibody; OPHN3 antibody; Serine/threonine-protein kinase PAK 3 antibody; EC 2.7.11.1 antibody; Beta-PAK antibody; Oligophrenin-3 antibody; p21-activated kinase 3 antibody; PAK-3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase PAK 3 protein (70-190AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PAK3 Antibody (CSB-PA017407LA01HU)，的標記方式是Non-conjugated。對于PAK3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA017407LB01HU PAK3 Antibody, HRP conjugated ELISA
    FITC CSB-PA017407LC01HU PAK3 Antibody, FITC conjugated
    Biotin CSB-PA017407LD01HU PAK3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC).
  • 基因功能參考文獻：
    1. The miR-193b-3p/PAK3 axis might be a potential novel therapeutic target for OC. PMID: 29169729
    2. Authors have identified mutations in PAK3, CASK, and MECP2 that likely contribute to intellectual disability, and the findings extend the spectrum of mutations and phenotypes associated with X-linked intellectual disability. PMID: 28481730
    3. This study showed that PARK3 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples. PMID: 25981171
    4. This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes PAK3. PMID: 25666757
    5. Cdc42Hs binds to the effector domain of PAK3 PMID: 25109462
    6. Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. PMID: 23818969
    7. p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. PMID: 21949127
    8. potential role of PAK3 in the progression of ACTH-producing thymic carcinoid PMID: 20960100
    9. PAK3 is a key regulator of synapse formation and plasticity in the hippocampus. The MRX30 mutation might contribute to the cognitive deficits underlying this form of X-linked mental retardation. PMID: 15574732
    10. PAK3 mutations result in a specific form of X-linked mental retardation with fairly constant clinical features. PMID: 18523455
    11. PAK3 codes for a splice variant that contains a 45-bp alternatively spliced exon. The exon encodes 15 aa that are inserted in the regulatory domain. PAK3b displays a high kinase activity in starved cells that is not further stimulated by active GTPases. PMID: 12464619

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  • 相關疾病：
    Mental retardation, X-linked 30 (MRX30)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
  • 數據庫鏈接：

    HGNC: 8592

    OMIM: 300142

    KEGG: hsa:5063

    STRING: 9606.ENSP00000353864

    UniGene: Hs.593599