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  4. LGR6 Antibody

LGR6 Antibody

  • 中文名稱：
    LGR6兔多克隆抗體
  • 貨號：
    CSB-PA884515LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate
      All lanes: LGR6 antibody at 2.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 105, 90, 100 kDa
      Observed band size: 105 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA884515LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA884515LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) LGR6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ14471 antibody; Gonadotropin receptor antibody; GPCR antibody; Leucine rich repeat containing G protein coupled receptor 6 antibody; Leucine-rich repeat-containing G-protein coupled receptor 6 antibody; Lgr6 antibody; LGR6_HUMAN antibody; VTS20631 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 6 protein (839-962AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，LGR6 Antibody (CSB-PA884515LA01HU)，的標記方式是Non-conjugated。對于LGR6 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA884515LB01HU LGR6 Antibody, HRP conjugated ELISA
    FITC CSB-PA884515LC01HU LGR6 Antibody, FITC conjugated
    Biotin CSB-PA884515LD01HU LGR6 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
  • 基因功能參考文獻：
    1. Inhibition of LGR6 promoted the osteogenic differentiation of bone marrow stromal cells in vitro. PMID: 29625528
    2. Lgr6 has a tumorpromoting role in the development of colorectal cancer. PMID: 29693156
    3. Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance. PMID: 27798604
    4. Two of the three monoclonal antibodies recognized the large N-terminal extracellular domain of leucine rich repeat containing G protein-coupled receptor 6 (LGR6), and competitively blocked the binding of R-spondin 1, which is known to be the ligand for LGR6. PMID: 28013222
    5. LGR6 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    6. Overexpression of wild-type LGR6 in HeLa cells leads to increased cell migration. PMID: 22615920

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數據庫鏈接：

    HGNC: 19719

    OMIM: 606653

    KEGG: hsa:59352

    STRING: 9606.ENSP00000356247

    UniGene: Hs.497402