日韩在线视频不卡-日一区二区三区-天堂国产+人+综合+亚洲欧美-精品国产一区二区三区久久狼-国产成人无码18禁午夜福利网址-国产在线拍偷自揄拍精品-九色91丨porny丨丝袜-久久天天躁狠狠躁夜夜av-99蜜桃臀久久久欧美精品-成人一区二区视频-狠狠操人人干-40岁干柴烈火少妇高潮不断-国产福利不卡-伊人98-丰满多毛的陰户视频-日韩一二三四五区-国产专区一线二线三线码-好男人社区影院www-国产精品2019-欧美三级一区

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. SEC24D Recombinant Monoclonal Antibody

SEC24D Recombinant Monoclonal Antibody

  • 中文名稱：
    SEC24D Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA298448A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of SEC24D expression in C2C12 cells using SEC24D antibody. Green, isotype control; red, SEC24D.
    • Immunocytochemical staining of C2C12 cells with SEC24D antibody. Nuclei were stained blue with DAPI; SEC24D was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using SEC24D antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with SEC24D antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    SEC24D; SEC24 Homolog D, COPII Coat Complex Component; KIAA0755; Protein Transport Protein Sec24D; SEC24-Related Protein D; SEC24 (S. Cerevisiae) Related Gene Family, Member D; SEC24 Family, Member D (S. Cerevisiae); SEC24 Related Gene Family, Member D; SEC24 Family Member D; CLCRP2
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human SEC24D protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    22H8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor TMED10. May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5.
  • 基因功能參考文獻：
    1. The study found missense mutations in the SEC24D gene in Chinese families with autosomal recessive osteogenesis imperfect. PMID: 27942778
    2. three mutant SEC24D alleles in a rare autosomal-recessively inherited skeletal disorder characterized by pre- and postnatal bone fragility, skull ossification defects, craniofacial dysmorphism, and short stature PMID: 25683121
    3. Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter PMID: 20889976
    4. concentrative endoplasmic reticulum-export is contingent on a direct interaction of GAT1 with Sec24D. PMID: 17210573
  • 相關疾病：
    Cole-Carpenter syndrome 2 (CLCRP2)
  • 亞細胞定位：
    Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
  • 蛋白家族：
    SEC23/SEC24 family, SEC24 subfamily
  • 組織特異性：
    Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver.
  • 數據庫鏈接：

    HGNC: 10706

    OMIM: 607186

    KEGG: hsa:9871

    STRING: 9606.ENSP00000280551

    UniGene: Hs.189641