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  4. PLAA Recombinant Monoclonal Antibody

PLAA Recombinant Monoclonal Antibody

  • 中文名稱：
    PLAA Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA929118A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of phospholipase A2 activating protein expression in HepG2 cells using phospholipase A2 activating protein antibody. Green, isotype control; red, phospholipase A2 activating protein.
    • Immunocytochemical staining of HepG2 cells with Phospholipase A2 activating protein antibody. Nuclei were stained blue with DAPI; Phospholipase A2 activating protein was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using phospholipase A2 activating protein antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with phospholipase A2 activating protein antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    PLAA; Phospholipase A2 Activating Protein; PLA2P; PLAP; DOA1; Phospholipase A-2-Activating Protein; FLJ11281; FLJ12699; DOA1 Homolog (S. Cerevisiae); DOA1 Homolog; NDMSBA
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PLAA protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    7B9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
  • 基因功能參考文獻(xiàn)：
    1. In both human and mouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysfunction syndrome with seizures. PMID: 28413018
    2. This study presented that Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. PMID: 28007986
    3. This review provides evidence that 1,25-dihydroxy vitamin D3 stimulates PLA2 via PLAA and CaMKII, a process initiated by Pdia3/PLAA interaction, which further triggers CaMKII-dependent PLA2 activation. [review] PMID: 25448737
    4. Function assignment to conserved residues in mammalian alkaline phosphatases. PMID: 11937510
    5. PLAP inhibits sPLA2-triggered release of fatty acids from erythrocyte membranes PMID: 14499668
    6. identified one stimulatory element, with Sp1 binding sites, and one inhibitory element, in exon 1 of the plaa gene PMID: 18291623
    7. Structural basis for ubiquitin recognition by a novel domain from the human phospholipase A2-activating protein PMID: 19423704

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  • 相關(guān)疾病：
    Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Cell junction, synapse.
  • 蛋白家族：
    WD repeat PLAP family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9043

    OMIM: 603873

    KEGG: hsa:9373

    STRING: 9606.ENSP00000380460

    UniGene: Hs.27182