RPAP2 Antibody

產(chǎn)品詳情

Uniprot No.：

Q8IXW5
基因名：

RPAP2
別名：

RPAP2 antibody; C1orf82 antibody; Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 antibody; EC 3.1.3.16 antibody; RNA polymerase II-associated protein 2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human RPAP2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.
基因功能參考文獻：
1. These results suggest that RPAP2 controls Pol II activity through a direct interaction with Rpb6 PMID: 25639305
2. During transcription of snRNA genes, Ser7 phosphorylation facilitates recruitment of RPAP2, which in turn both recruits Integrator and dephosphorylates Ser5. PMID: 22137580
亞細胞定位：

Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner.
蛋白家族：

RPAP2 family
數(shù)據(jù)庫鏈接：

HGNC: 25791

OMIM: 611476

KEGG: hsa:79871

STRING: 9606.ENSP00000359368

UniGene: Hs.444421