RFC2 Antibody

產品詳情

Uniprot No.：

P35250
基因名：

RFC2
別名：

A1 40 kDa subunit antibody; A1 antibody; Activator 1 40 kDa subunit antibody; Activator 1 antibody; Activator 1 subunit 2 antibody; MGC3665 antibody; OTTHUMP00000160645 antibody; OTTHUMP00000160646 antibody; Replication factor C (activator 1) 2 40kDa antibody; Replication factor C (activator 1) 2 antibody; Replication factor C 2 antibody; Replication factor C 40 kDa subunit antibody; Replication factor C subunit 2 antibody; RF C 40 kDa subunit antibody; RF-C 40 kDa subunit antibody; RFC 2 antibody; RFC 40 antibody; RFC 40 kDa subunit antibody; RFC2 antibody; RFC2_HUMAN antibody; RFC40 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human RFC2.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP.
基因功能參考文獻：
1. Upregulation by BCR/ABL requires activation of STAT5 and plays a key role in the BCR/ABL-mediated cell protection from apoptosis. PMID: 12036885
2. The cAMP functions as an upstream modulator that regulates the expression and nuclear translocation of RFC40 protein. PMID: 16413017
3. RPA plays a regulatory role in DNA damage responses via repression of RFC2 ubiquitylation in human cells. PMID: 18245774
相關疾病：

RFC2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region (PubMed:11003705).
亞細胞定位：

Nucleus.
蛋白家族：

Activator 1 small subunits family
數據庫鏈接：

HGNC: 9970

OMIM: 194050

KEGG: hsa:5982

STRING: 9606.ENSP00000055077

UniGene: Hs.647062