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  4. RAB6A Antibody

RAB6A Antibody

  • 中文名稱：
    RAB6A兔多克隆抗體
  • 貨號(hào)：
    CSB-PA918626
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from A549 cells, using RAB6A antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RAB6A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RAB6A
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER.
  • 基因功能參考文獻(xiàn)：
    1. Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. PMID: 27550519
    2. Rab6A binding to KIF1C's motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C's cellular functions. PMID: 25821985
    3. GORAB missense mutation disrupt RAB6 protein binding in genetic skin diseases. PMID: 26000619
    4. several analyses of vesicular transport demonstrated that Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells PMID: 25962623
    5. Data suggest that miR-5100 promotes tumor growth by facilitating the G1/S transition and targeting Rab6. PMID: 25754817
    6. Data indicate that myosin Va interacted with multiple new Rab subfamilies including Rab6, Rab14 and Rab39B. PMID: 24006491
    7. Mint1 826 bridges APP to the small GTPase PMID: 23737971
    8. The presence of an active pool of Rab6 within host cells early during infection is required to support efficient intracellular growth of L. pneumophila. PMID: 23569112
    9. Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. PMID: 23091056
    10. GTP-bound form of Rab6 promotes retrograde trafficking of cav-2 from the Golgi to ER PMID: 22607032
    11. the crystal structure of the human Rab6A'(Q72L) mutant form at 1.9A resolution is reported. PMID: 22750005
    12. Rab6 modulates the unfolded protein response (UPR), increased levels inhibit whereas decreased levels augment UPR induction. PMID: 22124028
    13. Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number PMID: 22335553
    14. Rab6 is required for Rab8A association with exocytotic vesicles. PMID: 21596566
    15. In contrast to wild-type R6IP1-Rab6 crystals, which took several weeks to grow to full size, the engineered R6IP1 (RPdel)-Rab6 crystals could be grown in a matter of days PMID: 21543860
    16. The authors found that the small GTPase Rab6 also interacts indirectly with cytomegalovirus pp150 through its interaction with Bicaudal D1. PMID: 21411515
    17. Data show that Rab6, a Golgi-associated Rab, forms a complex with myosin II, contributes to its localization at the Golgi complex and, unexpectedly, controls the fission of Rab6 vesicles. PMID: 20562865
    18. recombinant antibodies specific to the GTP-bound conformation of Rab6 were generated and used to locate Rab6; Rab6 was in its GTP-bound conformation on the Golgi apparatus and transport intermediates PMID: 12738866
    19. Rab6A and Rab6A' regulate microtubule-dependent recycling at the trans-Golgi network PMID: 15483056
    20. 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h. GTP binding activity, RaB small monomeric GTPase activity, protein transporter activity. PMID: 15747776
    21. Results show the crystal structure of the GTPase Rab6A in the GTP bound form. PMID: 16332443
    22. Rab6A' likely regulates the dynamics of the dynein/dynactin complex at the kinetochores and consequently the inactivation of the Mad2-spindle checkpoint. PMID: 16395330
    23. Results show that Rab6A and Rab6A' perform different functions within the cell and suggests a novel role for Rab6A' as the major Rab6 isoform regulating previously described Rab6-dependent transport pathways. PMID: 16536738
    24. role of the Rab6 isoforms in retrograde transport of ricin using both oligo- and vector-based RNAi assays PMID: 16683916
    25. a highly significant correlation between the Rab6 and the UPR marker BiP in Alzheimer disease brains. PMID: 17573808
    26. These data demonstrate that although Rab6 is not essential for secretion, it controls the organization of exocytosis within the cellular space. PMID: 17681140
    27. Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG. PMID: 17699596
    28. DYNLRB1 specifically interacts with all three Rab6 isoforms and co-localises at the Golgi. PMID: 18044744
    29. Data show that iPLA(1)gamma is a novel membrane transport factor that contributes to a specific Golgi-to-ER retrograde pathway distinct from presently characterized COPI- and Rab6-dependent pathways. PMID: 19632984
    30. Study demonstrates that Golgi recruitment of endogenous GCC185 does not involve Rab6A/A' and Arl1. PMID: 19703403

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  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Lipid-anchor.; [Isoform 1]: Golgi apparatus membrane; Lipid-anchor.; [Isoform 2]: Golgi apparatus membrane; Lipid-anchor.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9786

    OMIM: 179513

    KEGG: hsa:5870

    STRING: 9606.ENSP00000311449

    UniGene: Hs.503222