GUCA2B Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GUCA2B Polyclonal antibody
Uniprot No.：

Q16661
基因名：

GUCA2B
別名：

GUCA2B antibody; GCAP II antibody; GCAP-II antibody; Guanylate cyclase activator 2B (uroguanylin) antibody; Guanylate cyclase activator 2B antibody; Guanylate cyclase C-activating peptide II antibody; GUC2B_HUMAN antibody; GUCA2B antibody; UGN antibody; Uroguanylin antibody
宿主：

Rabbit
反應種屬：

human,Mouse,Rat
免疫原：

Human uroguanylin
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
基因功能參考文獻：
1. The simulations suggested that all missense SNPs considered as convergent deleterious caused some kind of structural change to the uroguanylin peptide. Additionally, four of these SNPs were also shown to cause modifications in peptide flexibility, possibly resulting in functional changes. PMID: 27620667
2. Uroguanylin concentrations are increased in patients with chronic renal failure, nephrotic syndrome, or those on dialysis. PMID: 15780094
3. The occurrences of the C-A haplotype (rs883062-rs1047047) and the C-A-G haplotype (rs883062-rs1047047-rs2297566) were significantly higher in the essential hypertension group than in the controls. PMID: 18037771
亞細胞定位：

Secreted.
蛋白家族：

Guanylin family
組織特異性：

Stomach and intestine.
數據庫鏈接：

HGNC: 4683

OMIM: 601271

KEGG: hsa:2981

STRING: 9606.ENSP00000361662

UniGene: Hs.32966