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  4. FBXO6 Antibody

FBXO6 Antibody

  • 中文名稱：
    FBXO6兔多克隆抗體
  • 貨號：
    CSB-PA008515GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    F box protein that recognizes sugar chains 2 antibody; F box G domain protein 2 antibody; F box only protein 6 antibody; F box protein 6 antibody; F box protein FBG2 antibody; F box protein Fbx6 antibody; F box/G domain protein 2 antibody; F-box only protein 6 antibody; F-box protein that recognizes sugar chains 2 antibody; F-box/G-domain protein 2 antibody; FBG 2 antibody; FBG2 antibody; FBS 2 antibody; FBS2 antibody; FBX 6 antibody; FBX6 antibody; FBX6_HUMAN antibody; FBXO 6 antibody; FBXO6 antibody; OTTHUMP00000002267 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human FBXO6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
  • 基因功能參考文獻：
    1. FBXO6 as a functional E3 ubiquitin ligase for Ero1L that plays a critical role in inhibiting endoplasmic reticulum stress-induced apoptosis. PMID: 27855403
    2. It might inhibit cadmium-induced ER stress by functioning as a ubiquitin ligase in the ERAD system, thereby attenuating the cell death induced by subsequent JNK1 activation. PMID: 25374377
    3. systematical identification of the FBXO6-interacting glycoproteins, critical for clarifying its substrates as well as biological functions. PMID: 22268729
    4. Two interacting proteins of human FBXO6 protein have been found using the service in the study. PMID: 22292078
    5. Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD PMID: 12939278
    6. Fbx6-dependent Chk1 degradation contributes to S phase checkpoint termination and that a defect in this mechanism might increase tumor cell resistance to certain anticancer drugs. PMID: 19716789

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  • 亞細胞定位：
    Cytoplasm.
  • 數據庫鏈接：

    HGNC: 13585

    OMIM: 605647

    KEGG: hsa:26270

    STRING: 9606.ENSP00000365944

    UniGene: Hs.464419