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  4. DNAJC10 Antibody

DNAJC10 Antibody

  • 中文名稱：
    DNAJC10兔多克隆抗體
  • 貨號(hào)：
    CSB-PA809006LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA809006LA01HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Western Blot
      Positive WB detected in: HL60 whole cell lysate, SH-SY5Y whole cell lysate, Rat liver tissue, Rat brain tissue
      All lanes: DNAJC10 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 92, 87, 38 kDa
      Observed band size: 80 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DNAJC10 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DNAJC10 antibody; ERDJ5 antibody; UNQ495/PRO1012DnaJ homolog subfamily C member 10 antibody; EC 1.8.4.- antibody; Endoplasmic reticulum DNA J domain-containing protein 5 antibody; ER-resident protein ERdj5 antibody; ERdj5 antibody; Macrothioredoxin antibody; MTHr antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human DnaJ homolog subfamily C member 10 protein (521-793AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DNAJC10 Antibody (CSB-PA809006LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于DNAJC10 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA809006LB01HU DNAJC10 Antibody, HRP conjugated ELISA
    FITC CSB-PA809006LC01HU DNAJC10 Antibody, FITC conjugated
    Biotin CSB-PA809006LD01HU DNAJC10 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
  • 基因功能參考文獻(xiàn)：
    1. Role of ERdj5 conformational dynamics in endoplasmic reticulum associated degradation PMID: 28479060
    2. ERdj5 is a member of the proteostasis network that regulates rod opsin biogenesis and supports a role for disulfide bond formation/reduction in rod opsin biogenesis and disease. PMID: 25055872
    3. ERdj5, by binding to Sel1L, triggers BiP-Cholera toxin interaction proximal to the Hrd1 complex; postulate this scenario enables the Hrd1-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP PMID: 23363602
    4. ERdj5 acts as the endoplasmic reticulum reductase, both preparing misfolded proteins for degradation and catalyzing the folding of proteins that form obligatory non-native disulfides. PMID: 23769672
    5. ERdj5 is a ubiquitous protein localized in the ER and is particularly abundant in secretory cells. Its transcription is induced during ER stress, suggesting potential roles for ERdj5 in protein folding and translocation across the ER membrane. PMID: 12411443
    6. JPDI may have roles in folding of some proteins in the ER, chaperoning by BiP and formation of proper disulfide bonds PMID: 12446677
    7. The organization of the functional motifs of hMTHr suggests that the protein might be a member of a molecular chaperone family. PMID: 14587667
    8. ERdj4 and ERdj5 promote turnover of misfolded SP-C and this activity is dependent on their ability to stimulate BiP ATPase activity. PMID: 18400946
    9. study found that an endoplasmic reticulum (ER) protein ERdj5 had a reductase activity, cleaved the disulfide bonds of misfolded proteins & accelerated ER-associated degradation through its physical and functional associations with EDEM & BiP PMID: 18653895
    10. ERdj5 decreases neuroblastoma cell survival by down-regulating the UPR, raising the possibility that this protein could be a target for anti-tumor approaches. PMID: 19122239

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum lumen.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24637

    OMIM: 607987

    KEGG: hsa:54431

    STRING: 9606.ENSP00000264065

    UniGene: Hs.516632