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中文名稱：
CDC23兔多克隆抗體
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貨號：
CSB-PA001498
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規格：
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圖片：
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：
ANAPC8 antibody; Anaphase promoting complex subunit 8 antibody; Anaphase-promoting complex subunit 8 antibody; Apc 8 antibody; APC8 antibody; Cdc 23 antibody; CDC23 antibody; CDC23_HUMAN antibody; cell division cycle 23 antibody; Cell division cycle 23 homolog antibody; Cell division cycle protein 23 antibody; Cell division cycle protein 23 homolog antibody; Cut23 antibody; Cyclosome subunit 8 antibody
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宿主：
Rabbit
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反應種屬：
Human,Mouse,Monkey
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免疫原：
Synthesized peptide derived from the Internal region of Human Cdc23.
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免疫原種屬：
Homo sapiens (Human)
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標記方式：
Non-conjugated
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抗體亞型：
IgG
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純化方式：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：
It differs from different batches. Please contact us to confirm it.
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保存緩沖液：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：
Liquid
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應用范圍：
WB, ELISA
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推薦稀釋比：
| Application |
Recommended Dilution |
| WB |
1:500-1:2000 |
| ELISA |
1:20000 |
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Protocols：
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儲存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點詳情
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功能：
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
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基因功能參考文獻：
- Results identified CDC23 as a miR-34c-regulated target that could be responsible for the miR-34c-induced cell cycle arrest. PMID: 25064703
- CDC23 is a critical regulator of cell cycle and cell growth, may be involved in thyroid cancer initiation and progression, and may explain the different tumor biology observed by gender. PMID: 21990323
- Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A PMID: 21336306
- We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 which are known to be key function elements. PMID: 12629511
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蛋白家族：
APC8/CDC23 family
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數據庫鏈接：
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