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  4. TXNDC5 Monoclonal Antibody

TXNDC5 Monoclonal Antibody

  • 中文名稱：
    TXNDC5 Monoclonal Antibody
  • 貨號：
    CSB-MA228070
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Thioredoxin domain containing 5 expression in HT-1080 cells using Thioredoxin domain containing 5 antibody. Green, isotype control; red, Thioredoxin domain containing 5.
    • Immunocytochemical staining of HT-1080 cells with Thioredoxin domain containing 5 antibody. Nuclei were stained blue with DAPI; Thioredoxin domain containing 5 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using thioredoxin domain containing 5 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with thioredoxin domain containing 5 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) TXNDC5 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    TXNDC5; Thioredoxin Domain Containing 5; ERp46; EndoPDI; PDIA15; Hcc-2; Protein Disulfide Isomerase Family A, Member 15; Endoplasmic Reticulum Resident Protein 46; Thioredoxin Domain-Containing Protein 5; Thioredoxin-Like Protein P46; ER Protein 46; FLJ21353; FLJ90810; MGC3178; Thioredoxin Domain Containing 5 (Endoplasmic Reticulum); Epididymis Secretory Sperm Binding Protein; Endothelial Protein Disulphide Isomerase; Endoplasmic Reticulum Protein ERp46; Thioredoxin Related Protein; EC 1.8.4.-; EC 5.3.4.1; UNQ364; STRF8; TLP46; HCC2
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TXNDC5 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    17F2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:2500-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.
  • 基因功能參考文獻：
    1. Hypoxia induces the expression of TXNDC5 via upregulating HIF-1alpha in colorectal cancer cells. PMID: 29749460
    2. TXNDC5 is also closely associated with rheumatoid arthritis, diabetes, hepatic steatosis and vitiligo. [review] PMID: 28604976
    3. High TXNDC5 expression is associated with renal cell carcinoma. PMID: 26810069
    4. we defined an important role of TXNDC5 in CRPC and further investigations are needed to screen TXNDC5 antagonists as a novel therapeutic approaches to treat PCa patients with Castration-resistant prostate cancer. PMID: 25500540
    5. Role of ERp46 in oxidative protein folding.Independent actions of ERp46 thioredoxin domains on folding substrates.Structure of thioredoxin ERp46 domains. PMID: 24462249
    6. suggest that the tumorigenic properties of ERp46 in RCC cells are not related to an inhibitory modulation of AdipoR1 PMID: 24594673
    7. Endo-PDI is a novel, important mediator of AP-1-driven gene expression and endothelial angiogenic function. PMID: 24103565
    8. TXNDC5 has increased expression in many tumors that is involved in the proliferation and migration of tumor cells, acting as a tumor-enhancing gene. PMID: 24100949
    9. results suggest that TXNDC5 polymorphisms could be related to the development of HCC in the Korean male population PMID: 24023338
    10. Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46. PMID: 23713588
    11. Hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in rheumatoid arthritis. PMID: 23326410
    12. Authors show that ERp46 is able to bind to a large pool of peptides containing aromatic and basic residues via all three of its catalytic domains (a(0), a and a'), though the a(0) domain may contain the primary binding site. PMID: 23376096
    13. crystal structure of the third catalytic domain of protein disulfide isomerase ERp46 (also known as protein disulfide isomerase A5 and TXNDC5) was determined to 2.0 A resolution PMID: 22505402
    14. TXNDC5 has a genetic effect on the risk of rheumatoid arthritis and ankylosing spondylitis PMID: 21801346
    15. Overexpression of the TXNDC5 protein is associated with non-small cell lung carcinoma. PMID: 21617212
    16. results suggest that TXNDC5 gene polymorphisms are associated with the development of nonsegmental vitiligo in the Korean population. PMID: 19906073
    17. TXNDC5 can promote the growth and proliferation of gastric cells. Silencing of TXNDC5 can restrain the growth and proliferation of gastric cancer cells. PMID: 20157732
    18. these results establish ERp46 as the first AdipoR1-specific interacting protein and suggest a role for ERp46 in adiponectin receptor biology and adiponectin signalling. PMID: 20074551
    19. ERp46 has specificity towards peroxiredoxin-4, a thioredoxin peroxidase. PMID: 19887585
    20. upregulation of TXNDC5 are involved in the early development of colorectal cancer PMID: 17895523
    21. Member of the protein disulphide isomerase family and highly expressed in endothelial cells. Protects endothelial cells from apoptosis under hypoxia. PMID: 12963716

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  • 亞細胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Protein disulfide isomerase family
  • 數據庫鏈接：

    HGNC: 21073

    OMIM: 616412

    KEGG: hsa:81567

    STRING: 9606.ENSP00000369081

    UniGene: Hs.150837