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CHMP5 Monoclonal Antibody

  • 中文名稱:
    CHMP5 Monoclonal Antibody
  • 貨號:
    CSB-MA278315
  • 規格:
    ¥1320
  • 圖片:
    • Flow cytometric analysis of Charged multivesicular body protein 5 expression in HepG2 cells using Charged multivesicular body protein 5 antibody. Green, isotype control; red, Charged multivesicular body protein 5.
    • Western blotting analysis using charged multivesicular body protein 5 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with charged multivesicular body protein 5 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他:

產品詳情

  • 產品名稱:
    Mouse anti-Homo sapiens (Human) CHMP5 Monoclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CHMP5; Charged Multivesicular Body Protein 5; Vps60; HSPC177; C9orf83; SNF7DC2; CGI-34; Vacuolar Protein Sorting-Associated Protein 60; SNF7 Domain-Containing Protein; Chromatin-Modifying Protein 5; HVps60; Chromosome 9 Open Reading Frame 83; Apoptosis-Related Protein PNAS-2; Chromatin Modifying Protein 5; SNF7 Domain Containing; PNAS-2
  • 宿主:
    Mouse
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human CHMP5 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Mouse IgG1
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    20A4
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, FC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:100-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
  • 基因功能參考文獻:
    1. CHMP5 might be involved in the homeostatic regulation of TCR on the cell surface, presumably through TCR recycling or degradation. Thus CHMP5 is implicated in TCR-mediated signaling. PMID: 26821576
    2. ESCRT-III protein CHMP5 inhibits LIP5-mediated VPS4 activation by inducing a moderate conformational change within LIP5. PMID: 25637630
    3. after CHMP5 inhibition, both Granzyme B/Perforin apoptotic pathway and apoptosis-inducing factor-mediated necrotic pathway were activated, while autophagic pathway was not activated PMID: 23619569
    4. PNAS-2 was shown to be anti-apoptotic and may participate in leukemogenesis PMID: 17855796
    5. pnas-2 is specifically up-regulated in acute leukemia patients. PMID: 18426649
    6. The pnas-2 gene may be closely related with apotosis of arsenic sulfide treated APL cells. PMID: 17708794

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  • 亞細胞定位:
    Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
  • 蛋白家族:
    SNF7 family
  • 數據庫鏈接:

    HGNC: 26942

    OMIM: 610900

    KEGG: hsa:51510

    STRING: 9606.ENSP00000223500

    UniGene: Hs.635313