日韩在线视频不卡-日一区二区三区-天堂国产+人+综合+亚洲欧美-精品国产一区二区三区久久狼-国产成人无码18禁午夜福利网址-国产在线拍偷自揄拍精品-九色91丨porny丨丝袜-久久天天躁狠狠躁夜夜av-99蜜桃臀久久久欧美精品-成人一区二区视频-狠狠操人人干-40岁干柴烈火少妇高潮不断-国产福利不卡-伊人98-丰满多毛的陰户视频-日韩一二三四五区-国产专区一线二线三线码-好男人社区影院www-国产精品2019-欧美三级一区

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 單克隆抗體
  4. CALCOCO2 Monoclonal Antibody

CALCOCO2 Monoclonal Antibody

  • 中文名稱：
    CALCOCO2 Monoclonal Antibody
  • 貨號：
    CSB-MA979487
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of CALCOCO2 expression in HeLa cells using CALCOCO2 antibody. Green, isotype control; red, CALCOCO2.
    • Immunocytochemical staining of HeLa cells with CALCOCO2 antibody. Nuclei were stained blue with DAPI; CALCOCO2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and Smart Gain：Medium. Scale bar, 20 μm.
    • Western blotting analysis using CALCOCO2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CALCOCO2 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) CALCOCO2 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CALCOCO2; Calcium Binding And Coiled-Coil Domain 2; NDP52; Calcium-Binding And Coiled-Coil Domain-Containing Protein 2; Antigen Nuclear Dot 52 KDa Protein; Nuclear Domain 10 Protein NDP52; Nuclear Domain 10 Protein 52; Nuclear Dot Protein 52; MGC17318
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CALCOCO2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    1C5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.
  • 基因功能參考文獻：
    1. Backfolding of MVI regulates its ability to bind DNA and that a putative transcription co-activator NDP52 relieves the auto-inhibition of MVI to enable DNA binding. Additionally, we show that the MVI-NDP52 complex binds RNAPII, which is critical for transcription, and that depletion of NDP52 or MVI reduces steady-state mRNA levels. PMID: 29187741
    2. findings reveal a negative feedback loop of RLR signaling generated by Tetherin-MARCH8-MAVS-NDP52 axis and provide insights into a better understanding of the crosstalk between selective autophagy and optimal deactivation of type I IFN signaling. PMID: 28965816
    3. The authors propose that Rab35-GTP is a critical regulator of autophagy through recruiting autophagy receptor NDP52. PMID: 28848034
    4. The authors identify calcium-binding and coiled-coil domain 2 (CALCOCO2, also known as NDP52) as a binding partner of influenza A virus PB1-F2. PMID: 28613140
    5. Presence of the NDP52 rs2303015 minor variant increases the risk for spontaneous bacterial peritonitis in patients with alcoholic cirrhosis. PMID: 26493630
    6. insight into how CALCOCO2 targets ubiquitin-decorated pathogens for autophagic degradations PMID: 26506893
    7. control retrotransposon insertion in the genome PMID: 25366815
    8. These data show that NDP52 promotes the maturation of autophagosomes via its interaction with LC3A, LC3B, and/or GABARAPL2 through a distinct LC3-interacting region, and with MYOSIN VI. PMID: 25771791
    9. data support a model in which non-ND10 resident Sp100 acts as a negative regulator of polycomb repressive complex-2 (PRC2) recruitment, and suggest that KSHV may actively escape ND10 silencing mechanisms to promote establishment of latent chromatin. PMID: 25033267
    10. the role of ORF75 in the antagonization of ND10-mediated intrinsic immunity PMID: 24453968
    11. Dimeric NDP52 forms a ternary complex with two monomeric galectin-8 molecules as well as two LC3C molecules PMID: 23511477
    12. The missense SNP rs2303015 (Val248Ala) in the NDP52 was associated with Crohn's disease. PMID: 23624108
    13. Data indicate that the binding site in galectin-8 is essential for the recruitment of the autophagy receptor NDP52 to cytosol-exposed Salmonella Typhimurium. PMID: 23386746
    14. Autophagy of Tax1bp1/Ndp52 promotes non-canonical NF-kappaB signalling. PMID: 23209807
    15. Data show that the selectivity of the autophagy receptor NDP52 for LC3C is crucial for innate immunity since cells lacking either protein cannot protect their PMID: 23022382
    16. Data show that the miRNA-processing enzyme, DICER and the main miRNA effector, AGO2, are targeted for degradation as miRNA-free entities PMID: 23143396
    17. a selective autophagic mechanism mediated by NDP52 that works downstream of TRIF-TRAF6. PMID: 21964925
    18. p62 and NDP52 act cooperatively to drive efficient antibacterial autophagy by targeting the protein complexes they coordinate to distinct microdomains associated with bacteria PMID: 21079414
    19. p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. PMID: 21646350
    20. ND10 and ND10 components might be important defensive factors against the CMV cross-species infection PMID: 21552525
    21. interacts with ICP4 regulatory protein of HSV-1 during early stage of infection PMID: 14747555
    22. NDP52 was identified as a myosin VI binding protein; results suggest that myosin VI-T6BP-NDP52 complexes may play a role in coordinating cytokine signalling and membrane transport pathways with actin filament organisation and cell adhesion PMID: 17635994
    23. NDP52 recognizes ubiquitin-coated Salmonella enterica and recruits TBK1. PMID: 19820708

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
  • 蛋白家族：
    CALCOCO family
  • 組織特異性：
    Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain.
  • 數據庫鏈接：

    HGNC: 29912

    OMIM: 604587

    KEGG: hsa:10241

    STRING: 9606.ENSP00000258947

    UniGene: Hs.514920