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Your Good Partner in Biology Research

TAOK1

TAOK1,全稱為TAO kinase 1,常見(jiàn)別名包括MAP3K4、MEKK4蛋白、ARAF蛋白等。該蛋白參與細(xì)胞增殖、凋亡、遷移和形態(tài)變化等多種生物學(xué)過(guò)程,與微管穩(wěn)定性密切相關(guān),其活性變化會(huì)影響有絲分裂進(jìn)程。TAOK1蛋白在多種細(xì)胞信號(hào)通路中發(fā)揮關(guān)鍵作用,例如MAPK級(jí)聯(lián)反應(yīng)和Hippo信號(hào)通路。研究發(fā)現(xiàn)TAOK1過(guò)表達(dá)會(huì)異常激活JNK和p38 MAPK通路,導(dǎo)致細(xì)胞凋亡增加或遷移能力增強(qiáng),與某些癌癥的進(jìn)展相關(guān);而TAOK1表達(dá)降低則可能破壞Hippo通路,引起YAP/TAZ信號(hào)異常激活,促進(jìn)細(xì)胞過(guò)度增殖。TAOK1蛋白的突變可能導(dǎo)致其激酶活性異常,與多種神經(jīng)系統(tǒng)疾病相關(guān),如自閉癥譜系障礙和精神分裂癥。目前,TAOK1蛋白已被認(rèn)為是潛在的治療靶點(diǎn),特別是在神經(jīng)退行性疾病和癌癥領(lǐng)域,多個(gè)針對(duì)TAOK1蛋白的抑制劑和激活劑正在研發(fā)中,展現(xiàn)出其在疾病治療中的巨大潛力。

熱銷產(chǎn)品

TAOK1 Antibody (CSB-PA752101LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA752101LA01HU

IHC image of CSB-PA752101LA01HU diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA752101LA01HU

Immunofluorescence staining of Hela cells with CSB-PA752101LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA752101LA01HU

Western Blot
Positive WB detected in: A549 whole cell lysate, U251 whole cell lysate, SH-SY5Y whole cell lysate, 293 whole cell lysate
All lanes: TAOK1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 117, 47, 98 kDa
Observed band size: 117 kDa

TAOK1 Antibodies

TAOK1 for Homo sapiens (Human)

TAOK1 Proteins

TAOK1 Proteins for Rattus norvegicus (Rat)

TAOK1 Proteins for Mus musculus (Mouse)

TAOK1 Proteins for Homo sapiens (Human)