SIGLEC8

SIGLEC8，全稱唾液酸結(jié)合免疫球蛋白樣凝集素8，是一種主要在免疫細(xì)胞表面表達(dá)的細(xì)胞表面受體。該蛋白常見別名為CD226，通過識別含有唾液酸的糖鏈結(jié)構(gòu)，介導(dǎo)細(xì)胞與細(xì)胞或細(xì)胞與病原體間的相互作用，在免疫調(diào)節(jié)中發(fā)揮重要作用。SIGLEC8作為免疫抑制檢查點(diǎn)分子，能夠避免不必要的免疫反應(yīng)，其細(xì)胞特異性表達(dá)特性及內(nèi)吞能力使其成為靶向藥物遞送的合適分子。研究表明，SIGLEC8與多種疾病密切相關(guān)，包括自身免疫性疾病和癌癥。在自身免疫性疾病中，SIGLEC8的異常表達(dá)或功能可能導(dǎo)致免疫反應(yīng)失控，從而引發(fā)疾病；而在癌癥中，SIGLEC8的高表達(dá)與腫瘤細(xì)胞的免疫逃逸機(jī)制有關(guān)。針對SIGLEC8的藥物研發(fā)已取得一定進(jìn)展，例如抗SIGLEC-8單克隆抗體能夠通過抑制腫瘤細(xì)胞與免疫細(xì)胞的相互作用，增強(qiáng)抗腫瘤反應(yīng)。此外，基于SIGLEC8的抗體藥物、抗體-藥物偶聯(lián)物和嵌合抗原受體T細(xì)胞療法等新型治療策略也在臨床研究中展現(xiàn)出潛力。

熱銷產(chǎn)品

SIGLEC8 Recombinant Monoclonal Antibody (CSB-RA878931MA1HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-RA878931MA1HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

Human Sialic acid-binding Ig-like lectin 8(SIGLEC8) ELISA kit (CSB-EL021302HU)

驗(yàn)證數(shù)據(jù)

貨號：CSB-EL021302HU

規(guī)格：96T/48T

靈敏度：0.039 ng/mL

檢測范圍：0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

SIGLEC8 Antibody

SIGLEC8 Protein

SIGLEC8 ELISA Kit

SIGLEC8 Antibodies

SIGLEC8 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA005297	SIGLEC8 Antibody	Human	WB, ELISA
CSB-PA919371	SIGLEC8 Antibody	Human	ELISA,WB
CSB-PA555966	SIGLEC8 Antibody	Human	ELISA,IHC
CSB-RA878931MA1HU	SIGLEC8 Recombinant Monoclonal Antibody	Human	ELISA, IHC

SIGLEC8 Proteins

SIGLEC8 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP878931HU CSB-EP878931HU CSB-BP878931HU CSB-MP878931HU CSB-EP878931HU-B	Recombinant Human Sialic acid-binding Ig-like lectin 8 (SIGLEC8), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli