RIPK4
RIPK4,全稱為Receptor-interacting serine/threonine-protein kinase 4,是一種參與細胞程序性死亡、炎癥反應和免疫應答等關鍵生物學過程的絲氨酸/蘇氨酸蛋白激酶。該蛋白在表皮、角質形成細胞和某些免疫細胞中高表達,主要通過NF-κB和MAPK信號通路參與皮膚發育、傷口愈合和先天免疫防御。RIPK4蛋白的表達水平與多種疾病的發生發展密切相關,包括皮膚癌、卵巢癌、宮頸癌和結腸直腸癌等。近年來,RIPK4蛋白已成為癌癥治療的一個吸引人的靶點,多個針對RIPK4的藥物研發項目正在推進中,其中不乏一些具有突破性進展的項目。例如,維泰瑞隆公司申報的1類新藥SIR2501片獲得了臨床試驗默示許可,計劃用于治療肌萎縮側索硬化癥(ALS),即人們常說的“漸凍癥”。此外,RIPK4蛋白還在自身免疫性疾病中發揮重要作用,例如銀屑病等。針對RIPK4蛋白的藥物研發,有望為這些疾病患者帶來新的治療選擇。
熱銷產品
驗證數據
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA436282(RIPK4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA436282(RIPK4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
RIPK4 Antibodies
RIPK4 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA436282 | RIPK4 Antibody | Human | ELISA,IHC |
| CSB-PA087089 | RIPK4 Antibody | Human | ELISA,IHC |
RIPK4 Proteins
RIPK4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP019738HU CSB-EP019738HU CSB-BP019738HU CSB-MP019738HU CSB-EP019738HU-B |
Recombinant Human Receptor-interacting serine/threonine-protein kinase 4 (RIPK4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |






