IL3

IL3，即白細(xì)胞介素3，別名Interleukin-3、MCGF。IL-3主要由活化的T細(xì)胞和NK細(xì)胞產(chǎn)生，此外，IL-1激活的人內(nèi)皮細(xì)胞、IgE激活的小鼠肥大細(xì)胞和胎盤細(xì)胞等也能產(chǎn)生IL-3。IL-3的作用機(jī)制主要通過(guò)與其受體結(jié)合并觸發(fā)細(xì)胞內(nèi)信號(hào)傳導(dǎo)過(guò)程來(lái)實(shí)現(xiàn)。IL-3與其受體α鏈（IL-3Rα）結(jié)合后，會(huì)進(jìn)一步與β鏈（IL-3Rβ，CD131）結(jié)合，形成異源二聚體或寡聚體，從而激活受體相關(guān)的Janus激酶（JAK），主要是JAK2。激活的JAK2募集STAT5并介導(dǎo)其磷酸化，磷酸化的STAT5進(jìn)入細(xì)胞核，誘導(dǎo)下游效應(yīng)基因的轉(zhuǎn)錄。此外，IL-3還激活Ras-MAPK和磷酸肌醇3-激酶（PI3K）通路。IL-3是一種重要的造血生長(zhǎng)因子，對(duì)多種細(xì)胞類型的發(fā)育起著關(guān)鍵作用，包括粒細(xì)胞、單核細(xì)胞、巨噬細(xì)胞、嗜酸性粒細(xì)胞、嗜堿性粒細(xì)胞和肥大細(xì)胞。IL-3還參與免疫調(diào)節(jié)、炎癥反應(yīng)以及血液系統(tǒng)疾病的治療。

熱銷產(chǎn)品

Recombinant Human Interleukin-3 (IL3) (Active) (CSB-MP011652HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 0.3149 to 1.023 ng/mL.

Recombinant Human Interleukin-3 (IL3) (Active) (CSB-EP011652HUc7)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 5.972-17.16 ng/mL.

IL3 Antibody

IL3 Protein

IL3 ELISA Kit

IL3 Antibodies

IL3 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA011652GA01HU	IL3 Antibody	Human	ELISA,WB
CSB-PA06725B0Rb	IL3 Antibody, HRP conjugated	Human	ELISA
CSB-PA06725A0Rb	IL3 Antibody	Human	ELISA, IHC
CSB-PA011652ESR1HU	IL3 Antibody	Human	ELISA, IHC
CSB-PA196621	IL3 Antibody	Human,Mouse	ELISA,WB

IL3 Proteins

IL3 Proteins for Macaca mulatta (Rhesus macaque)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP011652MOW CSB-EP011652MOW CSB-BP011652MOW CSB-MP011652MOW CSB-EP011652MOW-B	Recombinant Macaca mulatta (Rhesus macaque) Interleukin-3 (IL3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP001981MOW	Recombinant Rhesus Macaque Interleukin-3 protein (IL3)	E.Coli

IL3 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP011652BO CSB-BP011652BO CSB-MP011652BO CSB-EP011652BO-B	Recombinant Bovine Interleukin-3 (IL3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL3 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-EP011652MO CSB-BP011652MO CSB-EP011652MO-B	Recombinant Mouse Interleukin-3 (Il3)	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-AP003291MO	Recombinant Mouse Interleukin-3 protein (Il3), partial	E.Coli

IL3 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP011652RA CSB-EP011652RA CSB-BP011652RA CSB-MP011652RA CSB-EP011652RA-B	Recombinant Rat Interleukin-3 (Il3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP011652HU CSB-BP011652HU CSB-EP011652HU-B	Recombinant Human Interleukin-3 (IL3)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP011652HU	Recombinant Human Interleukin-3 (IL3)	E.coli
CSB-AP001701HU	Recombinant Human Interleukin-3 protein (IL3)(P27S) (Active)	E.Coli
CSB-EP011652HUc7	Recombinant Human Interleukin-3 (IL3) (Active)	E.coli
CSB-AP004521HU	Recombinant Human Interleukin-3 (IL3) (Active)	Mammalian cell
CSB-AP004531HU	Recombinant Human Interleukin-3 (IL3) (Active)	E.coli
CSB-AP005821HU	Recombinant Human Interleukin-3 (IL3), partial (Active) (GMP)	E.Coli
CSB-MP011652HU-WD	Recombinant Human Interleukin-3 (IL3) (Active)	Mammalian cell
CSB-YP011652HUd7	Recombinant Human Interleukin-3 (IL3) (Active)	Yeast
CSB-MP011652HU	Recombinant Human Interleukin-3 (IL3) (Active)	Mammalian cell

IL3 Proteins for Saguinus oedipus (Cotton-top tamarin)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP011652SWB CSB-EP011652SWB CSB-BP011652SWB CSB-MP011652SWB CSB-EP011652SWB-B	Recombinant Saguinus oedipus Interleukin-3 (IL3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL3 Proteins for Hylobates lar (Common gibbon)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP011652HXW CSB-EP011652HXW CSB-BP011652HXW CSB-MP011652HXW CSB-EP011652HXW-B	Recombinant Hylobates lar Interleukin-3 (IL3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL3 Proteins for Callithrix jacchus (White-tufted-ear marmoset)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP632965CYL CSB-EP632965CYL CSB-BP632965CYL CSB-MP632965CYL CSB-EP632965CYL-B	Recombinant Callithrix jacchus Interleukin-3 (IL3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL3 Proteins for Pan troglodytes (Chimpanzee)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP637919EQV CSB-EP637919EQV CSB-BP637919EQV CSB-MP637919EQV CSB-EP637919EQV-B	Recombinant Pan troglodytes Interleukin-3 (IL3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL3 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP860200DO CSB-EP860200DO CSB-BP860200DO CSB-MP860200DO CSB-EP860200DO-B	Recombinant Dog Interleukin-3 (IL3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli