IFNA2

IFNA2（干擾素-α2）是干擾素-α（IFN-α）家族成員之一，具有抗病毒、抗腫瘤和免疫調(diào)節(jié)功能。它是一種由約165-166個氨基酸殘基組成的蛋白質(zhì)，分子量約18-21 kDa，具有α-螺旋和β-折疊結(jié)構(gòu)域。IFNA2基因位于人類染色體9上，與其他IFN-α亞型基因聚集。其主要功能包括激活細胞內(nèi)抗病毒防御機制、抑制腫瘤細胞增殖、促進腫瘤細胞凋亡以及增強免疫細胞活性。IFNA2通過與其受體結(jié)合，激活JAK-STAT信號通路，進而磷酸化STAT蛋白，導(dǎo)致它們二聚化并轉(zhuǎn)移到細胞核中，調(diào)控干擾素刺激基因（ISGs）的表達。此外，IFNA2還涉及PI3K-AKT和MAPK信號通路，參與細胞生存、增殖、分化和凋亡等過程。臨床上，IFNA2被用于治療乙型和丙型肝炎以及某些類型的癌癥，盡管治療效果可能受到個體差異、病毒抗性和副作用的影響。

熱銷產(chǎn)品

Recombinant Human Interferon alpha-2 (IFNA2) (Active) (CSB-MP360706HU)

驗證數(shù)據(jù)

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IFNA2 at 2 μg/ml can bind Human IFNAR2(CSB-MP011047HU). The EC₅₀ is 154.2-191.9 ng/mL.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IFNA2 at 2 μg/ml can bind Anti-IFNA2 recombinant antibody(CSB-RA360706MA2HU). The EC₅₀ is 2.366-2.818 ng/mL.

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Recombinant Human Interferon alpha-2 (IFNA2) (CSB-EP360706HUe3)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IFNA2 Antibody

IFNA2 Protein

IFNA2 ELISA Kit

IFNA2 Antibodies

IFNA2 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA06504D0Rb	IFNA2 Antibody, Biotin conjugated	Human	ELISA
CSB-PA06504B0Rb	IFNA2 Antibody, HRP conjugated	Human	ELISA
CSB-PA06504A0Rb	IFNA2 Antibody	Human, Mouse	ELISA,WB?
CSB-PA250552	IFNA2 Antibody	Human	ELISA,IHC
CSB-PA048892	IFNA2 Antibody	Human	ELISA,IHC

IFNA2 Proteins

IFNA2 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP360706HU	Recombinant Human Interferon alpha-2 (IFNA2)	Yeast
CSB-EP360706HU	Recombinant Human Interferon alpha-2 (IFNA2)	E.coli
CSB-AP002761HU	Recombinant Human Interferon alpha-2 protein (IFNA2)	Yeast
CSB-AP002771HU	Recombinant Human Interferon alpha-2 protein (IFNA2), partial (Active)	E.Coli
CSB-AP002781HU	Recombinant Human Interferon alpha-2 protein (IFNA2)	Yeast
CSB-BP360706HU CSB-EP360706HU-B	Recombinant Human Interferon alpha-2 (IFNA2)	Baculovirus In Vivo Biotinylation in E.coli
CSB-AP004191HU	Recombinant Human Interferon alpha-2 (IFNA2) (Active)	E.coli
CSB-EP360706HUe3	Recombinant Human Interferon alpha-2 (IFNA2)	E.coli
CSB-MP360706HU	Recombinant Human Interferon alpha-2 (IFNA2) (Active)	Mammalian cell
CSB-MP360706HU-WD	Recombinant Human Interferon alpha-2 (IFNA2) (Active)	Mammalian cell