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Your Good Partner in Biology Research

FGF1

FGF1,即成纖維細(xì)胞生長(zhǎng)因子1,是一種重要的信號(hào)蛋白,也被稱為酸性成纖維細(xì)胞生長(zhǎng)因子(aFGF)。該蛋白參與多種生理過程,包括細(xì)胞增殖、血管生成和組織修復(fù)。FGF1通過與成纖維細(xì)胞生長(zhǎng)因子受體(FGFR)結(jié)合,激活下游信號(hào)級(jí)聯(lián)反應(yīng),從而影響細(xì)胞行為和基因表達(dá)。在疾病方面,F(xiàn)GF1與肥胖、2型糖尿病、非酒精性脂肪性肝病、癌癥和心臟病等多種疾病相關(guān)。研究表明,F(xiàn)GF1在調(diào)節(jié)肝臟炎癥、維持穩(wěn)態(tài)以及抗氧化應(yīng)激等方面發(fā)揮重要作用。然而,長(zhǎng)期使用FGF1可能導(dǎo)致腫瘤發(fā)生風(fēng)險(xiǎn)增加,限制了其在臨床治療中的應(yīng)用。目前,研究人員正致力于開發(fā)針對(duì)FGF1的靶向藥物,以降低其副作用并提高治療效果。例如,溫州醫(yī)科大學(xué)的李校堃團(tuán)隊(duì)發(fā)現(xiàn)FGF1在腸肝疾病中的關(guān)鍵作用,為開發(fā)基于FGF1的精準(zhǔn)治療策略提供了新思路。

熱銷產(chǎn)品

Recombinant Human Fibroblast growth factor 1 (FGF1) (CSB-EP008615HU)

驗(yàn)證數(shù)據(jù)

CSB-EP008615HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FGF1 Recombinant Monoclonal Antibody (CSB-RA008615MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA008615MA1HU

Immunofluorescence staining of U251 cell with CSB-RA008615MA1HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

CSB-RA008615MA1HU

Overlay Peak curve showing PC-3 cells stained with CSB-RA008615MA1HU (red line) at 1:200. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was mouse IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

FGF1 Antibody (CSB-PA008615ESR1HU)

驗(yàn)證數(shù)據(jù)

CSB-PA008615ESR1HU

Western blot
All lanes: Fibroblast growth factor 1 antibody at 6μg/ml
Lane 1: Mouse kidney tissue
Lane 2: Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 18, 7 kDa
Observed band size: 18 kDa

CSB-PA008615ESR1HU

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA008615ESR1HU at dilution of 1:100

CSB-PA008615ESR1HU

IHC image of CSB-PA008615ESR1HU diluted at 1:289 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA008615ESR1HU

IHC image of CSB-PA008615ESR1HU diluted at 1:289 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA008615ESR1HU

Immunofluorescence staining of Hela cells with CSB-PA008615ESR1HU at 1:96, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human acidic fibroblast growth factor,aFGF/FGF-1 ELISA Kit (CSB-E04546h)

驗(yàn)證數(shù)據(jù)

CSB-E04546h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E04546h

規(guī)格:96T/48T

靈敏度:3.9 pg/mL

檢測(cè)范圍:15.6 pg/mL-1000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

FGF1 Antibodies

FGF1 for Homo sapiens (Human)

FGF1 for Mus musculus (Mouse)

FGF1 Proteins

FGF1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

FGF1 Proteins for Sus scrofa (Pig)

FGF1 Proteins for Gallus gallus (Chicken)

FGF1 Proteins for Mus musculus (Mouse)

FGF1 Proteins for Rattus norvegicus (Rat)

FGF1 Proteins for Bos taurus (Bovine)

FGF1 Proteins for Homo sapiens (Human)

FGF1 Proteins for Mesocricetus auratus (Golden hamster)

FGF1 Proteins for Pongo abelii (Sumatran orangutan)

FGF1 Proteins for Notophthalmus viridescens (Eastern newt) (Triturus viridescens)

FGF1 Proteins for Xenopus laevis (African clawed frog)

FGF1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

FGF1 Proteins for Cynops pyrrhogaster (Japanese common newt)

FGF1 Proteins for Ovis aries (Sheep)

FGF1 Proteins for Capreolus capreolus (Roe deer)

FGF1 ELISA Kit

FGF1 ELISA Kit for Homo sapiens (Human)

FGF1 ELISA Kit for Mus musculus (Mouse)