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ANXA1

ANXA1,即膜聯(lián)蛋白A1,別名lipocortinI。ANXA1由人類ANXA1基因編碼,該基因定位于染色體9q24,含有13個外顯子和12個內(nèi)含子。ANXA1是一種鈣依賴的磷脂結(jié)合蛋白,屬于Annexins家族中的一員,其核心區(qū)域含有四個重復(fù)的“2型”鈣結(jié)合域基團和一個N端結(jié)構(gòu)域。當細胞質(zhì)中的ANXA1與鈣離子結(jié)合后,會向細胞膜轉(zhuǎn)移并與之結(jié)合,從而暴露N端結(jié)構(gòu)域,該結(jié)構(gòu)域是ANXA1的主要功能結(jié)構(gòu)域,主要通過與甲酰基肽受體FPR2結(jié)合發(fā)揮抗炎癥反應(yīng)和促進溶解的作用。ANXA1在多種細胞生命活動中發(fā)揮作用,包括抗炎癥反應(yīng)、細胞分化和增殖、細胞死亡信號調(diào)控、凋亡細胞吞噬清除等。

熱銷產(chǎn)品

Recombinant Human Annexin A1 (ANXA1), partial (CSB-EP001836HU1)

驗證數(shù)據(jù)

CSB-EP001836HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP001836HU1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP134574h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) ANX1.

CSB-EP001836HU1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP134574h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) ANX1.

ANXA1 Recombinant Monoclonal Antibody (CSB-RA001836MA1HU)

驗證數(shù)據(jù)

CSB-RA001836MA1HU

IHC image of CSB-RA001836MA1HU diluted at 1:30 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA001836MA1HU

Overlay Peak curve showing MCF7 cells stained with CSB-RA001836MA1HU (red line) at 1:400. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,016 events was performed.

ANXA1 Antibodies

ANXA1 for Homo sapiens (Human)

ANXA1 for Mus musculus (Mouse)

ANXA1 Proteins

ANXA1 Proteins for Mus musculus (Mouse)

ANXA1 Proteins for Cavia cutleri (Guinea pig)

ANXA1 Proteins for Sus scrofa (Pig)

ANXA1 Proteins for Bos taurus (Bovine)

ANXA1 Proteins for Oryctolagus cuniculus (Rabbit)

ANXA1 Proteins for Homo sapiens (Human)

ANXA1 Proteins for Pan troglodytes (Chimpanzee)

ANXA1 Proteins for Rodentia sp.

ANXA1 Proteins for Rattus norvegicus (Rat)

ANXA1 Proteins for Pongo abelii (Sumatran orangutan)

ANXA1 Proteins for Equus caballus (Horse)

ANXA1 Proteins for Gallus gallus (Chicken)

ANXA1 ELISA Kit

ANXA1 ELISA Kit for Homo sapiens (Human)

ANXA1 ELISA Kit for Mus musculus (Mouse)