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  4. PRSS2 Recombinant Monoclonal Antibody

PRSS2 Recombinant Monoclonal Antibody

  • 中文名稱：
    PRSS2重組抗體
  • 貨號：
    CSB-RA789332A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Immunofluorescence staining of Jurkat cell with CSB-RA789332A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 562-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA789332A0HU是一款針對PRSS2蛋白的重組單克隆抗體，適用于多種體外實(shí)驗(yàn)研究。PRSS2（絲氨酸蛋白酶2）屬于胰蛋白酶家族成員，主要參與消化酶原激活及蛋白水解過程，其表達(dá)異常與胰腺疾病、消化道腫瘤等病理機(jī)制密切相關(guān)。本產(chǎn)品經(jīng)嚴(yán)格驗(yàn)證，可在ELISA和免疫熒光（IF）實(shí)驗(yàn)中特異性識別PRSS2靶蛋白，其中IF實(shí)驗(yàn)推薦使用1:50-1:200的稀釋度，能夠清晰呈現(xiàn)目標(biāo)蛋白在細(xì)胞或組織樣本中的亞定位及表達(dá)水平。該抗體具有高批次間一致性和低交叉反應(yīng)性，適用于探索PRSS2在消化系統(tǒng)功能調(diào)控、腫瘤微環(huán)境重塑等領(lǐng)域的分子機(jī)制，為胰腺炎、結(jié)直腸癌等疾病的體外模型研究提供可靠工具。通過優(yōu)化生產(chǎn)工藝，本產(chǎn)品在抗原親和力及穩(wěn)定性方面表現(xiàn)優(yōu)異，可滿足基礎(chǔ)科研中對蛋白定量分析及細(xì)胞成像的多樣化需求。
  • Uniprot No.：
  • 基因名：
    PRSS2
  • 別名：
    Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II), PRSS2, TRY2 TRYP2
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human PRSS2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    12H7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    In the ileum, may be involved in defensin processing, including DEFA5.
  • 基因功能參考文獻(xiàn)：
    1. evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis PMID: 26110235
    2. PRSS2 single nucleotide polymorphism associated with the development of alcoholic pancreatitis. PMID: 25253127
    3. Serum trypsinogen-2 is associated with pancreatic cancer and pancreatitis. PMID: 25916077
    4. trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms. PMID: 22909050
    5. Elevation of urine trypsinogen 2 is an independent risk factor for pancreatic fistula after pancreaticoduodenectomy. PMID: 22357509
    6. Report a simple, rapid, easy, and noninvasive urinary trypsinogen-2 test can diagnose or rule out most cases of acute pancreatitis. PMID: 22481290
    7. Data show that urinary trypsinogen-2 dipstick test is a useful test for early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21946810
    8. results suggest that trypsinogen-2 is a more sensitive marker than amylase, and it can be useful in early diagnosis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. PMID: 21792081
    9. A genetic variant of PRSS2 may contribute to the low prevalence of pancreatitis in primary hyperparathyroidism patients. PMID: 20625975
    10. Hyperexpression of the PRSS2 gene is associated with pancreatic cancer. PMID: 20428826
    11. there was a borderline statistically significant association between pancreatic cancer and HAT/HCT but no association between pancreatic cancer and HAT, HCT. PMID: 20484960
    12. Urine trypsinogen-2 test may be an important diagnostic tool in excluding the diagnosis of acute pancreatitis; it has a negative predictive value. PMID: 20517765
    13. Results do not support the urinary trypsinogen-2 dipstick test (UTDT) to replace standard plasma amylase for the diagnosis of AP, however, the test demonstrated an adequate sensitivity to be used for rapid early screening of AP in daily clinics. PMID: 19752771
    14. Results indicate that up-regulation of anionic trypsinogen in pancreatic diseases does not affect physiological trypsinogen activation, but significantly limits trypsin generation under potential pathological conditions. PMID: 12709065
    15. High levels of pulmonary trypsin-2 may be associated with the development of bronchopulmonary dysplasia in preterm infants. PMID: 12949286
    16. G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis PMID: 16699518
    17. Our results suggest that serum trypsinogen-2 is a most useful marker for diagnosing patients with cholangiocarcinoma, and it is superior to serum CA19-9 and CEA. PMID: 17640760
    18. Co-localization of trypsin-2 and MMP-9 resulted in intracellular proMMP-9 processing that represented fully or partially activated MMP-9. PMID: 18062964
    19. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. PMID: 18362849
    20. A fusion with PRSS1 is associated with hereditary pancreatitis. PMID: 18461367
    21. primary role of trypsinogen sulfation in humans is to stimulate autoactivation of PRSS1 PMID: 18986305
    22. The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan. PMID: 19052022
    23. G191R PRSS2 is a rare allele in the Indian population and the data suggest a nonsignificant trend towards a protective effect from tropical calcific pancreatitis in Indians. PMID: 19077465

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  • 亞細(xì)胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    Peptidase S1 family
  • 組織特異性：
    Expressed in Paneth cells, at the base of small intestinal crypts.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9483

    OMIM: 601564

    KEGG: hsa:5645

    UniGene: Hs.449281