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  4. C1S Recombinant Monoclonal Antibody

C1S Recombinant Monoclonal Antibody

  • 中文名稱：
    C1S重組抗體
  • 貨號(hào)：
    CSB-RA003657MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA003657MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA003657MA1HU C1S重組單克隆抗體是針對(duì)補(bǔ)體系統(tǒng)關(guān)鍵成分C1酯酶亞基（C1S）開發(fā)的高特異性檢測(cè)工具。該抗體靶向的C1S蛋白作為經(jīng)典補(bǔ)體激活途徑C1復(fù)合物的核心蛋白酶，在機(jī)體免疫防御及炎癥調(diào)控中發(fā)揮重要作用，其異常表達(dá)與多種免疫相關(guān)病理過程密切相關(guān)。本產(chǎn)品經(jīng)ELISA和免疫組化（IHC）雙平臺(tái)嚴(yán)格驗(yàn)證，在石蠟包埋組織切片中表現(xiàn)出優(yōu)異抗原識(shí)別能力，推薦使用1:50-1:200稀釋度可獲得清晰特異性染色。通過重組表達(dá)系統(tǒng)生產(chǎn)及多級(jí)親和純化工藝，確保抗體批次間高度一致性，為補(bǔ)體通路調(diào)控機(jī)制、自身免疫性疾病模型建立及感染免疫應(yīng)答研究提供可靠實(shí)驗(yàn)支持，尤其適用于心血管、腎臟等器官的局部補(bǔ)體激活現(xiàn)象檢測(cè)。該試劑嚴(yán)格限定于體外科學(xué)研究領(lǐng)域，不涉及任何臨床相關(guān)用途。
  • Uniprot No.：
  • 基因名：
  • 別名：
    C1S Recombinant Monoclonal Antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human C1S protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    12F12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
  • 基因功能參考文獻(xiàn)：
    1. TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. PMID: 24695853
    2. Data indicate that complement C1s mRNA level was low in ICR-derived glomerulonephritis (ICGN) mice liver as compared with age-matched ICR mice. PMID: 23989031
    3. A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. PMID: 23592783
    4. Four positively charged amino acids on the serine protease domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement. PMID: 22855709
    5. Detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites. PMID: 20008834
    6. Interaction with the prime side residues at the cleavage point in C1s enhances the affinity of the enzyme for complement 2 and complement 4 substrates; these prime subsite residues mediate positive cooperativity in the cleavage of the substrate. PMID: 14674770
    7. full specificity of the enzyme using a randomized phage display library PMID: 16169853
    8. There are splice variants of C1s mRNA transcripts in normal human cells PMID: 18062908

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  • 相關(guān)疾病：
    Complement component C1s deficiency (C1SD); Ehlers-Danlos syndrome, periodontal type, 2 (EDSPD2)
  • 蛋白家族：
    Peptidase S1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1247

    OMIM: 120580

    KEGG: hsa:716

    STRING: 9606.ENSP00000328173

    UniGene: Hs.458355