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  4. YTHDC1 Antibody, FITC conjugated

YTHDC1 Antibody, FITC conjugated

  • 中文名稱：
    YTHDC1兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA853467LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) YTHDC1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    YTHDC1 antibody; KIAA1966 antibody; YT521 antibody; YTH domain-containing protein 1 antibody; Splicing factor YT521 antibody; YT521-B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human YTH domain-containing protein 1 protein (89-153AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10. Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May also regulate alternative splice site selection. Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs. Also recognizes and binds m6A on other RNA molecules. Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist. Also recognizes and binds m6A-containing single-stranded DNA. Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing.
  • 基因功能參考文獻：
    1. YTHDC1 is involved in MAT2A mRNA stability control. PMID: 29262316
    2. Here, the authors show that the N(6)-methyladenosine-binding protein YTHDC1 mediates export of methylated mRNA from the nucleus to the cytoplasm in HeLa cells. PMID: 28984244
    3. Without proper localization of these processing factors it is difficult to establish a direct link between mRNA m6A methylation and mRNA splicing, although it is likely that YTHDC1 is mechanistically involved PMID: 27050931
    4. Results show that YTHDC1 promotes exon inclusion in targeted mRNAs through recruiting pre-mRNA splicing factor SRSF3 while blocking SRSF10 mRNA binding. PMID: 26876937
    5. The YTHDC1-binding sites and biochemical experiments, not only reveal the specific mode of m(6)A-YTH binding but also explain the preferential recognition of the GG(m(6)A)C sequences by YTHDC1. PMID: 25242552
    6. Hypoxia induces a specific switch in YT521 expression pattern towards the two non-protein coding mRNA variants, the already characterized isoform 3 and the newly discovered exon 8-skipping isoform. PMID: 23765422
    7. Studied mRNA levels of FOXO1, KLF9 and YT521 in human normal and cancerous endometrial tissue. A remarkable (not significant, p = 0.069) increase was found in the YT521 mRNA level of patients' endometrial tissue in comparison with the control subjects. PMID: 23865345
    8. Lack of YT521 protein is associated with endometrial cancer. PMID: 20686370
    9. YT521-B has a role in a gene expression in the pathogenesis of Emery-Dreifuss muscular dystrophy PMID: 12755701
    10. phosphorylation causes sequestration of YT521-B in an insoluble nuclear form, which is unable to change splice sites PMID: 15175272

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  • 亞細胞定位：
    Nucleus. Nucleus speckle.
  • 數據庫鏈接：

    HGNC: 30626

    KEGG: hsa:91746

    STRING: 9606.ENSP00000339245

    UniGene: Hs.175955