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  4. UBE2O Antibody, FITC conjugated

UBE2O Antibody, FITC conjugated

  • 中文名稱：
    UBE2O兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA866339LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) UBE2O Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    E2 230K antibody; EC=6.3.2.19 antibody; FLJ12878 antibody; KIAA1734 antibody; Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme antibody; RP23 193A16.5 antibody; UBE2O antibody; UBE2O_HUMAN antibody; Ubiquitin carrier protein O antibody; Ubiquitin conjugating enzyme E2 O antibody; Ubiquitin conjugating enzyme E2 of 230 kDa antibody; ubiquitin conjugating enzyme E2O antibody; Ubiquitin protein ligase O antibody; Ubiquitin-conjugating enzyme E2 O antibody; Ubiquitin-conjugating enzyme E2 of 230 kDa antibody; Ubiquitin-conjugating enzyme E2-230K antibody; Ubiquitin-protein ligase O antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human (E3-independent) E2 ubiquitin-conjugating enzyme protein (10-277AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.
  • 基因功能參考文獻：
    1. UBE2O is a self-contained quality control factor that comprises substrate recognition and ubiquitin transfer activities within a single protein to efficiently target orphans of multiprotein complexes for degradation. PMID: 28774922
    2. UBE2O mediates c-Maf polyubiquitination and degradation, induces MM cell apoptosis, and suppresses myeloma tumor growth, which provides a novel insight in understanding myelomagenesis and UBE2O biology. PMID: 28673317
    3. UBE2O specifically targets AMPKalpha2 for ubiquitination and degradation, and thereby promotes activation of the mTOR-HIF1alpha pathway. PMID: 28162974
    4. UBE2O defines an atypical ubiquitin-signaling pathway that coordinates the function of BAP1. PMID: 24703950
    5. UBE2O negatively regulates TRAF6-mediated NF-kappaB activation by inhibiting TRAF6 polyubiquitination. PMID: 23381138
    6. monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis PMID: 23455153

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm.
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 組織特異性：
    Predominantly expressed in skeletal muscle and heart.
  • 數據庫鏈接：

    HGNC: 29554

    OMIM: 617649

    KEGG: hsa:63893

    STRING: 9606.ENSP00000323687

    UniGene: Hs.16130