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  4. TTF2 Antibody

TTF2 Antibody

  • 中文名稱：
    TTF2兔多克隆抗體
  • 貨號：
    CSB-PA120090
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA120090(TTF2 Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    F2 antibody; Factor 2 antibody; Factor2 antibody; HuF 2 antibody; HuF2 antibody; Human factor 2 antibody; Lodestar homolog antibody; Lodestar protein antibody; RNA polymerase II termination factor antibody; Transcription release factor 2 antibody; Transcription termination factor 2 antibody; Transcription termination factor RNA polymerase II antibody; TTF2 antibody; TTF2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human TTF2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:5-1:20
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.
  • 基因功能參考文獻：
    1. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing PMID: 12927788
    2. TTF2 is the only ATP-dependent termination activity associated with Pol II transcription elongation complexes, is largely unaffected by template position, and is impervious to the phosphorylation state of the polymerase. PMID: 15125840
    3. Importantly, the mitotic phenotype seen with TTF2-siRNA is rescued by expression of the siRNA-resistant GFP-tagged TTF2 proving that reduced TTF2 is responsible for the retention of RNA polymerase II on mitotic chromosomes. PMID: 15467445
  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 數據庫鏈接：

    HGNC: 12398

    OMIM: 604718

    KEGG: hsa:8458

    STRING: 9606.ENSP00000358478

    UniGene: Hs.32333