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  4. PYGB Antibody

PYGB Antibody

  • 中文名稱：
    PYGB兔多克隆抗體
  • 貨號：
    CSB-PA10065A0Rb
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA10065A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA10065A0Rb at dilution of 1:100
    • Western Blot
      Positive WB detected in: Mouse skeletal muscle tissue
      All lanes: PYGB antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 97 kDa
      Observed band size: 97 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PYGB Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Brain glycogen phosphorylase antibody; Glycogen phosphorylase B antibody; Glycogen phosphorylase brain form antibody; Glycogen Phosphorylase Isoenzyme BB antibody; Glycogen phosphorylase; brain form antibody; MGC9213 antibody; Phosphorylase glycogen brain antibody; PYGB antibody; PYGB_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Glycogen phosphorylase, brain form protein (6-843AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PYGB Antibody (CSB-PA10065A0Rb)，的標記方式是Non-conjugated。對于PYGB Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA10065B0Rb PYGB Antibody, HRP conjugated ELISA
    FITC CSB-PA10065C0Rb PYGB Antibody, FITC conjugated
    Biotin CSB-PA10065D0Rb PYGB Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  • 基因功能參考文獻：
    1. PYGB siRNA exerted an inhibitory effect on the cell viability of the human osteosarcoma cells MG63 and HOS by blocking the Caspase/Bcl and CDK1 signaling pathway, highlighting novel potential therapeutic methods for treating osteosarcoma. PMID: 29845265
    2. Using cysteine chemical labeling, mass spectrometry, and site-directed mutagenesis approaches, we show that thiram (and certain of its metabolites) alters the activity of bGP through the formation of an intramolecular disulfide bond (Cys(318)-Cys(326)), known to act as a redox switch that precludes the allosteric activation of bGP by AMP. PMID: 27965358
    3. disulfide bond acts as a redox switch that precludes the allosteric activation of the enzyme by AMP without affecting its activation by phosphorylation. This unique regulatory feature of bGP sheds new light on the isoform-specific regulation of glycogen phosphorylase and glycogen metabolism. PMID: 27660393
    4. the bGP structures reveal molecular features unique to the brain isozyme that provide a deeper understanding of the differences in the activation properties of these allosteric enzymes by the allosteric effector AMP. PMID: 27402852
    5. GPBB is a valuable biological marker to predict the prognosis in patient with acute coronary syndrome. PMID: 22818785
    6. H-FABP and GPBB can contribute to early acute myocardial infarction diagnosis and can distinguish acute myocardial infarction from acute coronary syndrome PMID: 22838188
    7. Significant increase in plasma glycoprotein BB in patients with hypertrophic cardiomyopathy. PMID: 20482380
    8. Brain-type glycogen phosphorylase is expressed in non-small-cell lung carcinoma, particularly adenocarcinomas, and is an independent poor prognostic factor. PMID: 17393985

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  • 蛋白家族：
    Glycogen phosphorylase family
  • 數據庫鏈接：

    HGNC: 9723

    OMIM: 138550

    KEGG: hsa:5834

    STRING: 9606.ENSP00000216962

    UniGene: Hs.368157