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  4. PLIN5 Antibody, FITC conjugated

PLIN5 Antibody, FITC conjugated

  • 中文名稱：
    PLIN5兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA804867LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PLIN5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Lipid storage droplet protein 5 antibody; LSDA5 antibody; MLDP antibody; OXPAT antibody; Perilipin 5 antibody; Perilipin-5 antibody; PLIN5 antibody; PLIN5_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Perilipin-5 protein (305-453AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
  • 基因功能參考文獻(xiàn)：
    1. The data highlight a key role of PLIN5 in lipid droplets function, first by finely adjusting lipid droplets fatty acids supply to mitochondrial oxidation, and second acting as a protective factor against lipotoxicity in skeletal muscle. PMID: 27922115
    2. Notch1 expression is reduced and glucose-6-phosphatase and perilipin-5 (G6PC/PLIN5) are upregulated in liver biopsies from nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) patients. PMID: 27428080
    3. High oxygen consumption in middle-aged men was reflected in higher perilipin 5 expression in skeletal muscle. PMID: 26447519
    4. PLIN5 was significantly colocated with ATGL, mitochondria and CGI-58, indicating a close association between the key lipolytic effectors in resting skeletal muscle. PMID: 25054327
    5. Perilipin 5 as a lipid droplet protein adapted to mitochondrial energy utilization PMID: 24535284
    6. Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5 PMID: 23129790
    7. PLIN5 likely plays an important role in intramyocellular lipid accumulation and oxidation, both of which increase with endurance training in human skeletal muscle. PMID: 22667335
    8. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. PMID: 22127648
    9. Perilipin 5 is the most recently established family member, highly expressed in oxidative tissues and could play an important role in regulating LD TAG hydrolysis in oxidative mammalian tissues. [Review] PMID: 21632259
    10. interaction of ATGL with CGI-58 increased lipolysis, whereas interaction of ATGL with perilipin 5 decreased lipolysis. PMID: 21393244
    11. Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes. PMID: 19602560

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  • 亞細(xì)胞定位：
    Lipid droplet. Cytoplasm. Mitochondrion.
  • 蛋白家族：
    Perilipin family
  • 組織特異性：
    Expressed in skeletal muscle, liver, heart and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 33196

    OMIM: 613248

    KEGG: hsa:440503

    STRING: 9606.ENSP00000371272

    UniGene: Hs.131034