日韩在线视频不卡-日一区二区三区-天堂国产+人+综合+亚洲欧美-精品国产一区二区三区久久狼-国产成人无码18禁午夜福利网址-国产在线拍偷自揄拍精品-九色91丨porny丨丝袜-久久天天躁狠狠躁夜夜av-99蜜桃臀久久久欧美精品-成人一区二区视频-狠狠操人人干-40岁干柴烈火少妇高潮不断-国产福利不卡-伊人98-丰满多毛的陰户视频-日韩一二三四五区-国产专区一线二线三线码-好男人社区影院www-国产精品2019-欧美三级一区

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PKD2L1 Antibody

PKD2L1 Antibody

  • 中文名稱：
    PKD2L1兔多克隆抗體
  • 貨號：
    CSB-PA865199DSR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA865199DSR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PKD2L1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PKD2L1
  • 別名：
    B830002B15 antibody; BC046386 antibody; PCL antibody; PK2L1 antibody; PK2L1_HUMAN antibody; PKD2L antibody; PKD2L1 antibody; PKDL antibody; Polycystic kidney disease 2 like 1 antibody; Polycystic kidney disease 2 like 1 protein antibody; Polycystic kidney disease 2-like 1 protein antibody; Polycystin L antibody; Polycystin-2 homolog antibody; Polycystin-2L1 antibody; Polycystin-L antibody; Polycystin-L1 antibody; Transient receptor potential cation channel subfamily P member 3 antibody; TRPP3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Polycystic kidney disease 2-like 1 protein (561-805AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration. The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription. Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells. The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again. May play a role in the perception of carbonation taste. May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH.
  • 基因功能參考文獻：
    1. The pore helix and transmembrane segment 6 of PKD2L1 are involved in upper and lower-gate opening, adopt an open conformation. PMID: 29567962
    2. PKD2 and PKD1 genes are mutated in autosomal dominant polycystic kidney disease. PKD2 can form either a homomeric cation channel or a heteromeric complex with the PKD1 receptor, presumed to respond to ligand(s) and/or mechanical stimuli. Here, we identify a two-residue hydrophobic gate in PKD2L1, and a single-residue hydrophobic gate in PKD2. PMID: 29899465
    3. palmitoylation at Cys-38 and phosphorylation at Thr-39 independently regulated TRPP3 channel function PMID: 27754867
    4. our study identified C1 as the first PKD2L1 domain essential for both PKD2L1 trimerization and channel function, and suggest that PKD2L1 and PKD2L1/PKD1L3 channels share the PKD2L1 trimerization process. PMID: 25820328
    5. Trimerization may be important for both homo- and possibly heteromeric assemblies of PKD2L1. PMID: 22193359
    6. This study demonistrated that human PKD2L play the role of food preference behavior. PMID: 22794107
    7. Pkd2L1 is a novel target channel whose function is regulated by the versatile scaffolding protein RACK1. PMID: 22174419
    8. Despite the moderate sequence identity between C-terminal regulatory domains (CRDs) of PKD2 and PKD2L1, they both form trimers, implying that trimeric organization of CRDs may be true of all polycystin channels. PMID: 20408813
    9. the PKD2L1-PKD1L3 complex is involved in acid sensing in vivo PMID: 20406802
    10. The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. PMID: 11959145
    11. Taken together, alpha-actinin not only attaches TRPP3 to the cytoskeleton but also up-regulates TRPP3 channel function. PMID: 17944866

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.
  • 蛋白家族：
    Polycystin family
  • 組織特異性：
    Detected in taste bud cells in fungiform papillae (at protein level). Ubiquitous. Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. Isoform 4 appears to be expressed only in transformed lymphoblasts.
  • 數據庫鏈接：

    HGNC: 9011

    OMIM: 604532

    KEGG: hsa:9033

    STRING: 9606.ENSP00000325296

    UniGene: Hs.159241