LPHN1 Antibody

產品詳情

Uniprot No.：

O94910
基因名：

ADGRL1
別名：

Calcium independent alpha latrotoxin receptor 1 antibody; Calcium-independent alpha-latrotoxin receptor 1 antibody; CIRL-1 antibody; CIRL1 antibody; CL1 antibody; CLIBA antibody; G protein-coupled receptor for alpha-Latrotoxin antibody; KIAA0821 antibody; Latrophilin 1 antibody; Latrophilin-1 antibody; Latrophilin1 antibody; LEC2 antibody; Lectomedin 2 antibody; Lectomedin-2 antibody; LPHN 1 antibody; LPHN1 antibody; LPHN1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human Latrophilin-1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
IF	1:200-1:1000
ELISA	1:5000

Protocols：

Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis.
基因功能參考文獻：
1. alterations in latrophilin expression occur in AML cells expressing P-gp PMID: 29938681
2. Our findings demonstrate that latrophilin-1 could be considered as a novel biomarker of human acute myeloid leukaemia PMID: 27322212
3. A single SNP in LPHN1 (rs3810256) was identified, with the minor allele increasing the risk of asthma. PMID: 27325752
4. In this article they evaluated the amount of p120-p85 complex still presented on the cellular membrane and confirmed that on cell surface major amount of mature CIRL-1 presented as a p120-p85 subunit complex. PMID: 20971062
亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome.
蛋白家族：

G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
數據庫鏈接：

HGNC: 20973

OMIM: 616416

KEGG: hsa:22859

STRING: 9606.ENSP00000340688

UniGene: Hs.94229