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  4. GTF2H5 Antibody

GTF2H5 Antibody

  • 中文名稱：
    GTF2H5兔多克隆抗體
  • 貨號：
    CSB-PA010014EA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA010014EA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA010014EA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA010014EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GTF2H5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GTF2H5 antibody; C6orf175 antibody; TTDA antibody; General transcription factor IIH subunit 5 antibody; General transcription factor IIH polypeptide 5 antibody; TFB5 ortholog antibody; TFIIH basal transcription factor complex TTD-A subunit antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human General transcription factor IIH subunit 5 protein (1-71AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，GTF2H5 Antibody (CSB-PA010014EA01HU)，的標記方式是Non-conjugated。對于GTF2H5 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA010014EB01HU GTF2H5 Antibody, HRP conjugated ELISA
    FITC CSB-PA010014EC01HU GTF2H5 Antibody, FITC conjugated
    Biotin CSB-PA010014ED01HU GTF2H5 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.
  • 基因功能參考文獻：
    1. Low levels of GTF2H5 are associated with enhanced prognosis in high-grade serous ovarian cancer patients and may contribute to cisplatin sensitization. PMID: 26463438
    2. Transcriptional differences found between various TFIIH subunit variants participate in the phenotypic variability observed among xeroderma pigmentosum, XP associated with Cockayne syndrome, and trichothiodystrophy individuals. PMID: 25620205
    3. Findings give new insights into the behavior of TTDA within the context of a living cell and thereby shed light on the complex phenotype of TTD-A patients. PMID: 23729738
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20522537
    5. p8/TTD-A, the tenth subunit of TFIIH, has a critical role in DNA repair where it triggers DNA opening by stimulating XPB ATPase activity together with the damage recognition factor XPC-hHR23B. PMID: 16427011
    6. TTDA is the first Transcription Factor IIH subunit with a primarily nucleotide excision repair-dedicated role in vivo. PMID: 16669699
    7. The solution structure of the p8/TTD-A protein, a small alpha/beta protein built around an antiparallel beta-sheet that forms a homodimer with an extended interface, is reported. PMID: 17350038
    8. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 18270339

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  • 相關疾病：
    Trichothiodystrophy 3, photosensitive (TTD3)
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    TFB5 family
  • 數據庫鏈接：

    HGNC: 21157

    OMIM: 608780

    KEGG: hsa:404672

    STRING: 9606.ENSP00000415032

    UniGene: Hs.356224