CELSR3 Antibody

中文名稱：

CELSR3兔多克隆抗體
貨號：

CSB-PA852817LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA852817LA01HU diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CELSR3 Polyclonal antibody
Uniprot No.：

Q9NYQ7
基因名：

CELSR3
別名：

Anchor protein antibody; Cadherin EGF LAG seven-pass G-type receptor 3 antibody; Cadherin family member 11 antibody; CDHF11 antibody; CELR3_HUMAN antibody; Celsr3 antibody; EGF like domain multiple 1 antibody; EGF-like protein 1 antibody; EGFL1 antibody; Epidermal growth factor-like protein 1 antibody; Flamingo antibody; Flamingo homolog 1 antibody; FMI1 antibody; hFmi1 antibody; MEGF2 antibody; Multiple EGF-like domains protein 2 antibody; Multiple epidermal growth factor-like domains protein 2 antibody; RESDA1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Cadherin EGF LAG seven-pass G-type receptor 3 protein (514-718AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CELSR3 Antibody (CSB-PA852817LA01HU)，的標記方式是Non-conjugated。對于CELSR3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA852817LB01HU	CELSR3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA852817LC01HU	CELSR3 Antibody, FITC conjugated
Biotin	CSB-PA852817LD01HU	CELSR3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Receptor that may have an important role in cell/cell signaling during nervous system formation.
基因功能參考文獻：
1. Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3), NIPBL (Nipped-B-like), and FN1 (fibronectin 1). PMID: 28472652
2. marked reduction in the prominence of TUJ1 bundles in number, thickness, and length. Our results showed that deregulation of the planar cell polarity genes CELSR3 and FZD3 might disrupt the enteric innervation pattern PMID: 27619161
3. A moderate positive correlation between CELSR3 and patient age was also evident. PMID: 26838213
4. seven-transmembrane domain receptors Celsr3 and Fzd3, in particular, control the development of most longitudinal tracts in the central nervous system. [Review] PMID: 25813877
5. CELSR3 promoter hypermethylation is associated with oral squamous cell carcinoma. PMID: 25374236
6. CELSR3 was found to be selectively up-regulated in tumor stellate cells. PMID: 20416094
7. CELSR3 is one of the core PCP signaling molecules. PMID: 16273260
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 2 family, LN-TM7 subfamily
數據庫鏈接：

HGNC: 3230

OMIM: 604264

KEGG: hsa:1951

STRING: 9606.ENSP00000164024

UniGene: Hs.631926