TYK2
TYK2，即酪氨酸激酶2，別名JTk1、 IMD35。TYK2是一種非受體酪氨酸激酶，屬于Janus激酶(JAK)家族成員之一，由人體細胞自身的基因編碼。它的作用機制主要是通過其激酶活性參與多種細胞因子的信號傳導，特別是與IL-12、IL-23、I型干擾素等細胞因子的信號轉導密切相關。TYK2通過與這些細胞因子的受體結合，激活下游的JAK-STAT信號通路，從而調(diào)控免疫細胞的增殖、分化和效應功能。TYK2在生物學上的意義非常廣泛，它在免疫應答、細胞增殖、分化以及腫瘤發(fā)生等過程中發(fā)揮著關鍵作用。TYK2的功能異常與多種疾病相關，包括銀屑病、炎癥性腸病、系統(tǒng)性紅斑狼瘡等自身免疫性疾病。因此，TYK2成為了藥物開發(fā)的熱門靶點，特別是針對其調(diào)節(jié)結構域的變構抑制劑，如deucravacitinib，已經(jīng)在治療銀屑病中顯示出良好的療效和安全性。這種變構抑制劑通過與TYK2的獨特結構域結合，實現(xiàn)了對TYK2的精準抑制，減少了其他JAK家族成員的不良影響，為治療相關免疫介導疾病提供了新的思路和方法。
熱銷產(chǎn)品
Recombinant Human Non-receptor tyrosine-protein kinase TYK2 (TYK2), partial (CSB-EP025391HU1)
驗證數(shù)據(jù)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP025391HU1 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TYK2.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP025391HU1 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TYK2.
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TYK2 Antibodies
TYK2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA154201 | Phospho-TYK2 (Tyr1054) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA906130 | TYK2 (Ab-1054) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA004352 | TYK2 Antibody | Human,Mouse,Monkey | WB, IHC, IF, ELISA |
| CSB-PA025391LA01HU | TYK2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA025391LB01HU | TYK2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA025391LC01HU | TYK2 Antibody, FITC conjugated | Human | |
| CSB-PA025391LD01HU | TYK2 Antibody, Biotin conjugated | Human | ELISA |
TYK2 Proteins
TYK2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025391HU CSB-EP025391HU CSB-BP025391HU CSB-MP025391HU CSB-EP025391HU-B |
Recombinant Human Non-receptor tyrosine-protein kinase TYK2 (TYK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP025391HU1 | Recombinant Human Non-receptor tyrosine-protein kinase TYK2 (TYK2), partial | E.coli |
| CSB-BP025391HU5 | Recombinant Human Non-receptor tyrosine-protein kinase TYK2 (TYK2), partial | Baculovirus |
| CSB-EP025391HU5 | Recombinant Human Non-receptor tyrosine-protein kinase TYK2 (TYK2), partial | E.coli |
| CSB-EP025391HU1a0 | Recombinant Human Non-receptor tyrosine-protein kinase TYK2 (TYK2), partial | E.coli |
TYK2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP865636MO CSB-BP865636MO CSB-MP865636MO CSB-EP865636MO-B |
Recombinant Mouse Non-receptor tyrosine-protein kinase TYK2 (Tyk2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP865636MO | Recombinant Mouse Non-receptor tyrosine-protein kinase TYK2 (Tyk2), partial | E.coli |
