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Your Good Partner in Biology Research

TRAF6

TRAF6 ,全稱為 TNF 受體相關因子 6,是一種重要的信號轉導蛋白,參與多種細胞因子和炎癥反應的調控。它也被稱為 MGC:3310、RNF85 等。TRAF6 蛋白在免疫系統(tǒng)中發(fā)揮著關鍵作用,與多種疾病的發(fā)生發(fā)展密切相關。研究表明,TRAF6 蛋白的異?;罨瘯е露喾N人類重大疾病,如成骨樣細胞炎、肝炎、心肌炎、胰腺炎、腸炎、動脈粥樣硬化或相關腫瘤等。
TRAF6 蛋白通過與多種蛋白結合,參與多種信號通路。例如,它可以與 ASK1、CD40、FHL2 等蛋白結合,激活 NFκB 信號通路,進而促進炎癥反應。此外,TRAF6 蛋白還參與 TLR 信號通路和 RANKL 信號通路的調控,影響免疫細胞的活化和趨化。
由于 TRAF6 蛋白在炎癥反應中的重要作用,它成為了一種潛在的藥物靶點。目前,已有研究表明,通過抑制 TRAF6 蛋白的活性,可以有效治療多種炎癥性疾病。例如,DRD5 蛋白的激動劑可以抑制 TRAF6 介導的 NFκB 信號通路的激活,從而發(fā)揮抗炎作用。此外,還有研究報道了 MST4 激酶可以調控 TRAF6 蛋白的活性,進而影響免疫炎癥反應。

熱銷產(chǎn)品

Recombinant Human TNF receptor-associated factor 6 (TRAF6) (CSB-EP024154HUe1)

驗證數(shù)據(jù)

CSB-EP024154HUe1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TRAF6 Recombinant Monoclonal Antibody (CSB-RA037392A0HU)

驗證數(shù)據(jù)

CSB-RA037392A0HU

IHC image of CSB-RA037392A0HU diluted at 1:100 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA037392A0HU

Immunofluorescence staining of Hela cell with CSB-RA037392A0HU at 1:50 , counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA037392A0HU

Overlay Peak curve showing SH-SY5Y cells stained with CSB-RA037392A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10, 000 events was performed.

TRAF6 Antibody (CSB-PA024154LA01HU)

驗證數(shù)據(jù)

CSB-PA024154LA01HU

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA024154LA01HU at dilution of 1:100

CSB-PA024154LA01HU

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA024154LA01HU at dilution of 1:100

CSB-PA024154LA01HU

Immunofluorescence staining of Hela cells with CSB-PA024154LA01HU at 1:333, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human tumor necrosis factor receptor-associated factor 6,TRAF6 ELISA kit (CSB-E14078h)

驗證數(shù)據(jù)

CSB-E14078h 標準曲線

貨號:CSB-E14078h

規(guī)格:96T/48T

靈敏度:9.8 pg/mL

檢測范圍:39 pg/mL-2500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TRAF6 Antibodies

TRAF6 for Homo sapiens (Human)

TRAF6 Proteins

TRAF6 Proteins for Mus musculus (Mouse)

TRAF6 Proteins for Sus scrofa (Pig)

TRAF6 Proteins for Rattus norvegicus (Rat)

TRAF6 Proteins for Macaca mulatta (Rhesus macaque)

TRAF6 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

TRAF6 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

TRAF6 Proteins for Homo sapiens (Human)

TRAF6 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

TRAF6 Proteins for Bos taurus (Bovine)

TRAF6 ELISA Kit

TRAF6 ELISA Kit for Homo sapiens (Human)