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TNFRSF17

TNFRSF17,全稱為腫瘤壞死因子受體超家族成員17,也被稱為B細(xì)胞成熟蛋白(BCMA)或CD269抗原,是腫瘤壞死因子受體(TNFR)超家族的跨膜糖蛋白成員。BCMA主要在B細(xì)胞增殖、存活以及分化為漿細(xì)胞方面發(fā)揮重要作用,并且是多發(fā)性骨髓瘤(MM)的生物標(biāo)志物。BCMA具有兩種激動劑配體:增殖誘導(dǎo)配體(APRIL)和B細(xì)胞激活因子(BAFF)。配體與BCMA結(jié)合后,可以激活B細(xì)胞,進(jìn)而促進(jìn)細(xì)胞周期檢查點(diǎn)、抗凋亡蛋白的表達(dá)以及細(xì)胞粘附分子、血管生成因子和免疫抑制分子的產(chǎn)生。BCMA可作為治療多發(fā)性骨髓瘤的靶點(diǎn),相關(guān)免疫療法包括CART細(xì)胞療法等已在臨床中得到應(yīng)用。目前,針對BCMA的藥物研發(fā)主要集中在靶向BCMA的單克隆抗體和免疫檢查點(diǎn)抑制劑等方面,部分藥物已進(jìn)入臨床試驗(yàn)階段。

熱銷產(chǎn)品

Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (Active) (CSB-MP023974HU1)

驗(yàn)證數(shù)據(jù)

CSB-MP023974HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP023974HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized BCMA at 2 μg/ml can bind Anti-BCMA recombinant antibody, the EC50 of human BCMA protein is 1.912-2.488 ng/ml.

CSB-MP023974HU1

Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B (CSB-MP897523HU1) at 10 μg/ml can bind human BCMA, the EC50 of human BCMA protein is 221.3-298.6 ng/ml.

CSB-MP023974HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

CSB-MP023974HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized human BCMA at 5 μg/ml can bind Biotinylated human TNFSF13B (CSB-MP897523HU1-B), the EC50 is 0.1752-0.3657 ng/ml.

Recombinant Human Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), partial (CSB-EP023974HU1)

驗(yàn)證數(shù)據(jù)

CSB-EP023974HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TNFRSF17 Antibody (CSB-PA220479)

驗(yàn)證數(shù)據(jù)

CSB-PA220479

Western blot analysis of L929 293T MCF7 HELA using CD269 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000

CSB-PA220479

Western blot analysis of K562/JK using CD269 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000

TNFRSF17 Antibodies

TNFRSF17 for Homo sapiens (Human)

TNFRSF17 Proteins

TNFRSF17 Proteins for Mus musculus (Mouse)

TNFRSF17 Proteins for Homo sapiens (Human)

TNFRSF17 ELISA Kit

TNFRSF17 ELISA Kit for Homo sapiens (Human)

TNFRSF17 ELISA Kit for Mus musculus (Mouse)