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SMUG1

Single-strand selective monofunctional uracil DNA glycosylase is a protein in humans that is encoded by SMUG1 gene. Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following

SMUG1 Antibodies

SMUG1 for Homo sapiens (Human)

SMUG1 Proteins

SMUG1 Proteins for Homo sapiens (Human)

SMUG1 Proteins for Bos taurus (Bovine)

SMUG1 Proteins for Mus musculus (Mouse)

SMUG1 Proteins for Rattus norvegicus (Rat)

SMUG1 Proteins for Xenopus laevis (African clawed frog)