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Your Good Partner in Biology Research

SIRT2

SIRT2,全稱為沉默信息調(diào)節(jié)因子2,該蛋白在細(xì)胞分化、代謝調(diào)控、細(xì)胞周期控制等方面發(fā)揮著重要作用。SIRT2蛋白能夠通過去乙酰化修飾多種底物,包括組蛋白、α-微管蛋白以及一些關(guān)鍵的轉(zhuǎn)錄因子,從而影響這些底物的活性和穩(wěn)定性。在神經(jīng)元中,SIRT2蛋白主要定位于細(xì)胞質(zhì),參與調(diào)控微管的穩(wěn)定性,對神經(jīng)元的發(fā)育和功能至關(guān)重要。研究表明,SIRT2蛋白的表達(dá)水平與年齡增長相關(guān),在老年小鼠的腦和脊髓中,SIRT2蛋白的表達(dá)量會隨著年齡的增長而增加,這可能與神經(jīng)退行性疾病的發(fā)生發(fā)展有關(guān)。
SIRT2蛋白在多種疾病中發(fā)揮重要作用,包括神經(jīng)退行性疾病、代謝性疾病和腫瘤等。例如,SIRT2蛋白的過表達(dá)可以促進(jìn)腸上皮細(xì)胞、角質(zhì)形成細(xì)胞和結(jié)直腸癌細(xì)胞的分化,而在成肌細(xì)胞、前體脂肪細(xì)胞等細(xì)胞中,SIRT2蛋白的過表達(dá)則可能抑制細(xì)胞的分化。此外,SIRT2蛋白還與炎癥、氧化應(yīng)激等病理過程密切相關(guān)。基于SIRT2蛋白的這些特性,研究人員已經(jīng)開發(fā)了多種針對SIRT2蛋白的小分子抑制劑,用于治療神經(jīng)退行性疾病、代謝性疾病和腫瘤等疾病。這些抑制劑在臨床前研究中顯示出良好的治療效果,有望成為治療這些疾病的新型藥物。

熱銷產(chǎn)品

SIRT2 Recombinant Monoclonal Antibody (CSB-RA061500A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA061500A0HU

Western Blot
, Positive WB detected in:U251 whole cell lysate(30μg), Jurkat whole cell lysate(30μg), COLO205 whole cell lysate(30μg), HEK293 whole cell lysate(30μg)
All lanes: SIRT2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 43 kDa
Observed band size: 36, 43 kDa
Exposure time:120s

CSB-RA061500A0HU

IHC image of CSB-RA061500A0HU diluted at 1:100 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA061500A0HU

IHC image of CSB-RA061500A0HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA061500A0HU

Immunofluorescence staining of HepG2 cell with CSB-RA061500A0HU at 1:50 , counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SIRT2 Antibody (CSB-PA812889LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA812889LA01HU

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA812889LA01HU at dilution of 1:100

CSB-PA812889LA01HU

Immunofluorescent analysis of Hela cells using CSB-PA812889LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

SIRT2 Antibodies

SIRT2 for Homo sapiens (Human)

SIRT2 Proteins

SIRT2 Proteins for Homo sapiens (Human)