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SIRPA

SIRPA,即信號調節蛋白α,別名Sirp-alpha-3p84、CD172a。它是一種I型跨膜蛋白,屬于免疫球蛋白超家族成員,主要在髓系細胞如巨噬細胞、單核細胞、樹突狀細胞等表面表達,也在神經細胞表面表達。SIRPA的作用機制是通過與CD47等配體結合,傳遞抑制性信號,抑制巨噬細胞的吞噬作用,從而在免疫調節中發揮重要作用。SIRPA的胞內結構域含有免疫受體酪氨酸抑制基序(ITIM),能夠通過去磷酸化作用調節細胞內的信號通路。SIRPA參與了多種生理和病理過程的調節,包括免疫應答、細胞吞噬、中樞神經系統發育以及定向造血干細胞移植等。SIRPA通過與CD47的相互作用,可以抑制巨噬細胞對靶細胞的吞噬,這一機制被腫瘤細胞利用來實現免疫逃逸。因此,SIRPA是腫瘤免疫治療中的一個潛在靶點,尤其是與PD-1-PD-L1阻斷劑聯合使用時,可能對某些類型的癌癥治療具有重要意義。

熱銷產品

Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial (Active) (CSB-MP021334HU)

驗證數據

CSB-MP021334HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP021334HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized SIRPA at 2 μg/ml can bind human CD47(CSB-MP004940HU), the EC50 of human SIRPA protein is 58.30-85.04 ng/ml.

CSB-MP021334HU

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

SIRPA Recombinant Monoclonal Antibody (CSB-RA443117A0HU)

驗證數據

CSB-RA443117A0HU

IHC image of CSB-RA443117A0HU diluted at 1:50 and staining in paraffin-embedded human stomach tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.13% DAB.

CSB-RA443117A0HU

IHC image of CSB-RA443117A0HU diluted at 1:50 and staining in paraffin-embedded human rectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.13% DAB.

CSB-RA443117A0HU

Overlay Peak curve showing U937 cells surface stained with CSB-RA443117A0HU (red line) at 1:50. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA) ELISA kit (CSB-EL021334HU)

驗證數據

CSB-EL021334HU 標準曲線

貨號:CSB-EL021334HU

規格:96T/48T

靈敏度:0.039 ng/mL

檢測范圍:0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

SIRPA Antibodies

SIRPA for Homo sapiens (Human)

SIRPA Proteins

SIRPA Proteins for Homo sapiens (Human)

SIRPA Proteins for Mus musculus (Mouse)

SIRPA Proteins for Rattus norvegicus (Rat)

SIRPA Proteins for Bos taurus (Bovine)

SIRPA ELISA Kit

SIRPA ELISA Kit for Homo sapiens (Human)