RGMA
RGMA是一種糖基磷脂酰肌醇錨定糖蛋白，在中樞神經系統中作為關鍵的軸突引導蛋白。其結構特性使其能夠與受體NEO1/neogenin結合，進而發揮多重功能。RGMA不僅調節神經管閉合、抑制神經突生長和皮層神經元分支，還參與調節炎癥反應，并在中樞神經系統疾病中發揮重要作用。在信號通路方面，RGMA通過與受體結合，激活一系列級聯反應，包括RHOA-ROCK1/Rho激酶信號通路的激活，導致神經元生長錐塌陷和神經突生長抑制。另外，RGMA也被發現可以通過Neogenin下游的FAK去磷酸化抑制人臍動脈內皮細胞管狀結構形成，從而抑制血管生成。
熱銷產品
Recombinant Human Repulsive guidance molecule A (RGMA), partial (Active) (CSB-MP836186HU1)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human RGMA at 2 μg/ml can bind Anti-RGMA recombinant antibody (CSB-RA836186MA1HU). The EC50 is 0.2160-0.4838 ng/mL.
RGMA Antibodies
RGMA for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA019628GA01HU | RGMA Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA836186LA01HU | RGMA Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA836186LB01HU | RGMA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA836186LC01HU | RGMA Antibody, FITC conjugated | Human | |
| CSB-PA836186LD01HU | RGMA Antibody, Biotin conjugated | Human | ELISA |
RGMA Proteins
RGMA Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP836186HU CSB-BP836186HU CSB-MP836186HU CSB-EP836186HU-B |
Recombinant Human Repulsive guidance molecule A (RGMA) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP836186HU | Recombinant Human Repulsive guidance molecule A (RGMA) | E.coli |
| CSB-BP836186HUd8 | Recombinant Human Repulsive guidance molecule A (RGMA) | Baculovirus |
