PRTN3
PRTN3，即蛋白酶3基因，別名Proteinase 3、Myeloblastin、Wegener Autoantigen、C-ANCA Antigen、AGP7、NP-4、PR-3。PRTN3基因位于19號(hào)染色體上，其表達(dá)產(chǎn)物為蛋白酶3，這是一種中性粒細(xì)胞分泌的主要絲氨酸蛋白酶之一。蛋白酶3具有多種生物學(xué)功能，包括降解多種組織蛋白、加工細(xì)胞因子和受體等，從而調(diào)控炎癥反應(yīng)。它與免疫系統(tǒng)和天然免疫系統(tǒng)中的細(xì)胞因子信號(hào)通路相關(guān)，參與了成熟常規(guī)樹突狀細(xì)胞分化、膜蛋白胞外域蛋白水解和中性粒細(xì)胞外滲等過程。與PRTN3基因相關(guān)的疾病包括肉芽腫病合并多發(fā)性血管炎和血管炎。此外，PRTN3基因還可能作為腫瘤免疫治療中激活細(xì)胞毒性免疫細(xì)胞的靶點(diǎn)，通過敲除或抑制其酶活性，可以促進(jìn)具有細(xì)胞毒性的免疫細(xì)胞如NK細(xì)胞和CD8+ T細(xì)胞的激活，從而有效抑制腫瘤的發(fā)展。
熱銷產(chǎn)品
Recombinant Human Myeloblastin (PRTN3),Biotinylated (CSB-EP018830HU-B)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PRTN3 Antibody (CSB-PA018830LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA018830LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA018830LA01HU at dilution of 1:100
PRTN3 Antibodies
PRTN3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018830LA01HU | PRTN3 Antibody | Human | ELISA, IHC |
| CSB-PA018830LB01HU | PRTN3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018830LC01HU | PRTN3 Antibody, FITC conjugated | Human | |
| CSB-PA018830LD01HU | PRTN3 Antibody, Biotin conjugated | Human | ELISA |
PRTN3 Proteins
PRTN3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018830HU CSB-BP018830HU CSB-MP018830HU |
Recombinant Human Myeloblastin (PRTN3) | Yeast Baculovirus Mammalian cell |
| CSB-EP018830HU | Recombinant Human Myeloblastin (PRTN3) | E.coli |
| CSB-EP018830HU-B | Recombinant Human Myeloblastin (PRTN3),Biotinylated | E.coli |
PRTN3 ELISA Kit
PRTN3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13058h | Human proteinase 3(PR3) ELISA kit | serum, tissue homogenates, plasma, urine | 0.195 ng/mL |
