PIKFYVE
PIKFYVE，全稱為phosphatidylinositol-3-phosphate 5-kinase，也被稱為PIKfyve或phosphatidylinositol-3-phosphate 5-kinase type III。該蛋白在細胞內(nèi)膜穩(wěn)態(tài)和內(nèi)體小泡的形成中發(fā)揮關(guān)鍵作用。它能夠磷酸化磷脂酰肌醇（PtdIns）的D-5位置，生成PtdIns5P和PtdIns(3,5)biphosphate，進而影響細胞骨架功能、膜運輸和受體信號傳導。PIKFYVE還參與ebola病毒和SARS-CoV-2的細胞進入過程，通過內(nèi)吞作用將病毒蛋白招募到細胞內(nèi)。此外，PIKFYVE與一些疾病的發(fā)生發(fā)展密切相關(guān)，如角膜點狀變性、胰腺癌等。針對PIKFYVE的藥物研發(fā)已取得一定進展，例如AcuraStem公司開發(fā)的AS-202反義寡核苷酸，已在治療肌萎縮性側(cè)索硬化癥（ALS）的臨床前研究中展現(xiàn)出良好效果。此外，PIKFYVE也被認為可能是治療COVID-19的有效靶點，相關(guān)抑制劑的研究正在進行中。
熱銷產(chǎn)品
PIKFYVE Antibody (CSB-PA896875DSR2HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA896875DSR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA896875DSR2HU at dilution of 1:100
PIKFYVE Antibodies
PIKFYVE for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018029GA01HU | PIKFYVE Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA072525 | PIKFYVE Antibody | Human,Mouse | ELISA,WB,IF |
| CSB-PA896875DSR2HU | PIKFYVE Antibody | Human | ELISA, IHC |
| CSB-PA003787 | PIKFYVE Antibody | Human,Mouse | WB, IF, ELISA |
| CSB-PA008031 | Phospho-PIKFYVE (S307) Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA008032 | PIKFYVE Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA594945 | PIKFYVE Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA924394 | PIKFYVE Antibody | Human,Mouse | ELISA,IHC |
PIKFYVE Proteins
PIKFYVE Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP896875HU CSB-EP896875HU CSB-BP896875HU CSB-MP896875HU CSB-EP896875HU-B |
Recombinant Human 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
