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PIAS1

E3 SUMO-protein ligase PIAS1 is a protein in humans that is encoded by PIAS1 gene. Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling.

PIAS1 Antibodies

PIAS1 for Homo sapiens (Human)

PIAS1 Proteins

PIAS1 Proteins for Mus musculus (Mouse)

PIAS1 Proteins for Homo sapiens (Human)