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PDIA3

PDIA3,即蛋白質二硫鍵異構酶A3(Protein disulfide-isomerase A3),別名58 kDa glucose-regulated protein、58 kDa microsomal protein (p58)、Disulfide isomerase ER-60。它屬于蛋白質二硫鍵異構酶(PDI)家族的成員,是一種在內質網中催化二硫鍵形成的酶,對蛋白質折疊和質量控制起著至關重要的作用。PDIA3作為分子伴侶,參與蛋白質的正確折疊、組裝和分泌,尤其在細胞應激反應中高度表達,能夠攔截與內質網應激相關的凋亡性細胞死亡。PDIA3在生物學上的意義非常廣泛,其表達在約70%的癌癥中升高,并且與腫瘤細胞的低侵襲性、存活和轉移能力有關。PDIA3還與免疫激活標志物、癌癥免疫細胞浸潤和免疫調節劑顯著相關,特別是能夠顯著預測抗PDL1治療反應。此外,PDIA3在T細胞受體(TCR)信號通路中具有調控作用,能夠促進T細胞的活化,參與調節T細胞TCR信號通路,影響ZAP70蛋白的磷酸化水平、CD69表達和IL-2的分泌,以及NF-κB信號通路。因此,PDIA3不僅在蛋白質合成、降解和分泌中發揮作用,塑造腫瘤微環境,還是癌癥預后和免疫治療反應的有力生物標志物,具有作為抗癌治療靶點的潛力。

熱銷產品

Recombinant Human Protein disulfide-isomerase A3 (PDIA3) (CSB-EP017720HU)

驗證數據

CSB-EP017720HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PDIA3 Antibody (CSB-PA005150)

驗證數據

CSB-PA005150

Western Blot analysis of A549 HT29 K562 cells using ERp57 Polyclonal Antibody

Human protein disulfide-isomerase A3,PDIA3 ELISA Kit (CSB-E09798h)

驗證數據

CSB-E09798h 標準曲線

貨號:CSB-E09798h

規格:96T/48T

靈敏度:0.31 ng/mL

檢測范圍:1.25 ng/mL-80 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

PDIA3 Antibodies

PDIA3 for Homo sapiens (Human)

PDIA3 Proteins

PDIA3 Proteins for Rattus norvegicus (Rat)

PDIA3 Proteins for Mus musculus (Mouse)

PDIA3 Proteins for Homo sapiens (Human)

PDIA3 Proteins for Bos taurus (Bovine)

PDIA3 Proteins for Papio hamadryas (Hamadryas baboon)

PDIA3 Proteins for Mesocricetus auratus (Golden hamster)

PDIA3 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

PDIA3 Proteins for Pongo abelii (Sumatran orangutan)

PDIA3 Proteins for Gallus gallus (Chicken)

PDIA3 ELISA Kit

PDIA3 ELISA Kit for Homo sapiens (Human)