NTN1

NTN1，即軸突生長(zhǎng)誘向因子1，是一種蛋白質(zhì)，由α-螺旋結(jié)構(gòu)組成，并由NTN1基因編碼。這種蛋白質(zhì)在神經(jīng)元的發(fā)育過(guò)程中扮演著重要的角色。NTN1通過(guò)與其受體識(shí)別并結(jié)合，引導(dǎo)神經(jīng)元軸突的生長(zhǎng)和突觸的形成。這種結(jié)合通常依賴(lài)于Ca2+離子的存在，通過(guò)受體激活內(nèi)源性信號(hào)傳導(dǎo)通路，最終影響神經(jīng)元的發(fā)育和功能。此外，Netrin-1能夠抑制腫瘤細(xì)胞的凋亡（細(xì)胞死亡），并促進(jìn)新血管生成以及控制成纖維細(xì)胞。Netrin-1還涉及上皮間質(zhì)轉(zhuǎn)化（EMT）過(guò)程。EMT與腫瘤的發(fā)生、進(jìn)展、轉(zhuǎn)移以及耐藥性緊密相關(guān)。阻斷Netrin-1可以抑制上皮細(xì)胞間質(zhì)轉(zhuǎn)化過(guò)程，進(jìn)而對(duì)腫瘤的發(fā)展產(chǎn)生重要影響。

熱銷(xiāo)產(chǎn)品

Recombinant Human Netrin-1 (NTN1), partial (Active) (CSB-MP016127HU(A4))

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human NTN1 at 2 μg/ml can bind Anti-NTN1 recombinant antibody (CSB-RA016127MA1HU).The EC₅₀ is 26.43-30.77 ng/mL.

NTN1 Antibody

NTN1 Protein

NTN1 ELISA Kit

NTN1 Antibodies

NTN1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA003404	NTN1 Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA006035	NTN1 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA016127LA01HU	NTN1 Antibody	Human	ELISA, WB, IHC
CSB-PA016127LC01HU	NTN1 Antibody, FITC conjugated	Human
CSB-PA016127LD01HU	NTN1 Antibody, Biotin conjugated	Human	ELISA

NTN1 Proteins

NTN1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP016127HU CSB-EP016127HU CSB-BP016127HU CSB-MP016127HU CSB-EP016127HU-B	Recombinant Human Netrin-1 (NTN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli