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NR3C1

NR3C1,別名GRL、GCCR。這個基因位于人類第5號染色體上,編碼的糖皮質激素受體在體內幾乎每個細胞中都有表達,并且調節控制發育、新陳代謝和免疫反應的基因。NR3C1的作用機制是通過與糖皮質激素如皮質醇結合,調節基因轉錄。未結合的受體存在于細胞的胞質溶膠中,與糖皮質激素結合后,受體-激素復合物可以進入細胞核,通過反式激活或反式抑制的方式調節基因表達。NR3C1在應對壓力源的短期和長期適應中發揮作用,可能對理解心理障礙,包括抑郁癥和創傷后應激障礙(PTSD)的某些或所有亞型至關重要。此外,NR3C1的異常表達與多種疾病的發生發展相關,如自身免疫疾病、代謝性疾病以及某些癌癥。

熱銷產品

Recombinant Human Glucocorticoid receptor (NR3C1), partial (CSB-EP016059HU1c2)

驗證數據

CSB-EP016059HU1c2

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NR3C1 Recombinant Monoclonal Antibody (CSB-RA958910A0HU)

驗證數據

CSB-RA958910A0HU

Western Blot
Positive WB detected in: 293 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, U87 whole cell lysate
All lanes: NR3C1 antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 86, 83, 82, 77, 76, 65, 61, 52, 51, 50 kDa
Observed band size: 95 kDa

CSB-RA958910A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA958910A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human Glucocorticoid receptor(NR3C1) ELISA kit (CSB-EL016059HU)

驗證數據

CSB-EL016059HU 標準曲線

貨號:CSB-EL016059HU

規格:96T/48T

靈敏度:7.81 pg/mL

檢測范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

NR3C1 Antibodies

NR3C1 for Homo sapiens (Human)

NR3C1 Proteins

NR3C1 Proteins for Homo sapiens (Human)

NR3C1 ELISA Kit

NR3C1 ELISA Kit for Homo sapiens (Human)