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NEIL2

Endonuclease 8-like 2 is a protein in humans that is encoded by NEIL2 gene. Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

NEIL2 Proteins

NEIL2 Proteins for Pongo abelii (Sumatran orangutan)

NEIL2 Proteins for Mus musculus (Mouse)

NEIL2 Proteins for Bos taurus (Bovine)

NEIL2 Proteins for Homo sapiens (Human)