MYD88

MYD88，即髓樣分化因子88。它是一種在造血干細(xì)胞和淋巴組織中表達(dá)的轉(zhuǎn)錄因子，廣泛參與免疫信號的傳遞。MYD88的來源是人體自身的基因編碼，它作為細(xì)胞內(nèi)傳遞信號的關(guān)鍵銜接蛋白，主要介導(dǎo)多種Toll樣受體（TLR）、白細(xì)胞介素1受體（IL-1R）及白細(xì)胞介素-18受體（IL-18R）的信號傳遞，在固有免疫中發(fā)揮顯著作用。MYD88的作用機(jī)制涉及到它與各種受體的相互作用，通過其TIR結(jié)構(gòu)域（Toll-白細(xì)胞介素1受體域）識別受體激活后的信號，進(jìn)而招募并激活下游的信號分子，如IRAK（白細(xì)胞介素-1受體相關(guān)激酶）等。這導(dǎo)致核因子-κB（NF-κB）和MAPK（絲裂原活化蛋白激酶）等轉(zhuǎn)錄因子的激活，從而調(diào)節(jié)炎癥因子的表達(dá)。MYD88的信號通路包括但不限于NF-κB通路、JAK-STAT3（酪氨酸激酶-信號轉(zhuǎn)導(dǎo)子和轉(zhuǎn)錄激活子3）信號通路等，這些通路在細(xì)胞增殖、分化以及炎癥反應(yīng)中扮演關(guān)鍵角色。MYD88的生物學(xué)意義主要體現(xiàn)在其對固有免疫應(yīng)答的調(diào)控上。它不僅參與病原體識別和炎癥反應(yīng)的啟動，還與腫瘤、感染性疾病、自身免疫性疾病等的發(fā)病機(jī)制密切相關(guān)。MYD88依賴的信號通路被認(rèn)為是這些疾病治療的潛在靶點(diǎn)。特別是，MYD88基因的某些突變，如L265P，可以導(dǎo)致炎癥因子產(chǎn)生增加，這在淋巴漿細(xì)胞淋巴瘤等疾病中尤為重要。因此，對MYD88的研究不僅有助于我們理解免疫應(yīng)答的復(fù)雜性，也為開發(fā)新的治療策略提供了可能。

熱銷產(chǎn)品

Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) (CSB-EP859945HU)

驗證數(shù)據(jù)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP859945HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MYD88.

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

MYD88 Antibody (CSB-PA859945LA01HU)

驗證數(shù)據(jù)

Immunofluorescent analysis of HepG2 cells using CSB-PA859945LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human myeloid differentiation factor 88, MyD88 ELISA Kit (CSB-E11747h)

驗證數(shù)據(jù)

貨號：CSB-E11747h

規(guī)格：96T/48T

靈敏度：0.078 ng/mL

檢測范圍：0.312ng/mL-20ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

MYD88 Antibody

MYD88 Protein

MYD88 ELISA Kit

MYD88 Antibodies

MYD88 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA003338	MYD88 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA995911	MYD88 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA859945LA01HU	MYD88 Antibody	Human	ELISA, IF
CSB-PA859945LB01HU	MYD88 Antibody, HRP conjugated	Human	ELISA
CSB-PA859945LC01HU	MYD88 Antibody, FITC conjugated	Human
CSB-PA859945LD01HU	MYD88 Antibody, Biotin conjugated	Human	ELISA

MYD88 Proteins

MYD88 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282MO CSB-EP015282MO CSB-BP015282MO CSB-MP015282MO CSB-EP015282MO-B	Recombinant Mouse Myeloid differentiation primary response protein MyD88 (Myd88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282PI CSB-EP015282PI CSB-BP015282PI CSB-MP015282PI CSB-EP015282PI-B	Recombinant Pig Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Gallus gallus (Chicken)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282CH CSB-EP015282CH CSB-BP015282CH CSB-MP015282CH CSB-EP015282CH-B	Recombinant Chicken Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Macaca mulatta (Rhesus macaque)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282MOW CSB-EP015282MOW CSB-BP015282MOW CSB-MP015282MOW CSB-EP015282MOW-B	Recombinant Macaca mulatta (Rhesus macaque) Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Ovis aries (Sheep)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282SH CSB-EP015282SH CSB-BP015282SH CSB-MP015282SH CSB-EP015282SH-B	Recombinant Sheep Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282TKY CSB-EP015282TKY CSB-BP015282TKY CSB-MP015282TKY CSB-EP015282TKY-B	Recombinant Takifugu rubripes Myeloid differentiation primary response protein MyD88 (myd88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Salmo salar (Atlantic salmon)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282SWI CSB-EP015282SWI CSB-BP015282SWI CSB-MP015282SWI CSB-EP015282SWI-B	Recombinant Salmo salar Myeloid differentiation primary response protein MyD88 (myd88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282MOV CSB-EP015282MOV CSB-BP015282MOV CSB-MP015282MOV CSB-EP015282MOV-B	Recombinant Macaca fascicularis Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282GGZ CSB-EP015282GGZ CSB-BP015282GGZ CSB-MP015282GGZ CSB-EP015282GGZ-B	Recombinant Gorilla gorilla gorilla Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Pan troglodytes (Chimpanzee)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282EQV CSB-EP015282EQV CSB-BP015282EQV CSB-MP015282EQV CSB-EP015282EQV-B	Recombinant Pan troglodytes Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282EQU CSB-EP015282EQU CSB-BP015282EQU CSB-MP015282EQU CSB-EP015282EQU-B	Recombinant Pan paniscus Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Pongo pygmaeus (Bornean orangutan)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282EXP CSB-EP015282EXP CSB-BP015282EXP CSB-MP015282EXP CSB-EP015282EXP-B	Recombinant Pongo pygmaeus Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015282DRI CSB-EP015282DRI CSB-BP015282DRI CSB-MP015282DRI CSB-EP015282DRI-B	Recombinant Cercocebus atys Myeloid differentiation primary response protein MyD88 (Myd88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP635725XBF CSB-EP635725XBF CSB-BP635725XBF CSB-MP635725XBF CSB-EP635725XBF-B	Recombinant Xenopus tropicalis Myeloid differentiation primary response protein MyD88 (myd88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP685436BO CSB-EP685436BO CSB-BP685436BO CSB-MP685436BO CSB-EP685436BO-B	Recombinant Bovine Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP708955OEI CSB-EP708955OEI CSB-BP708955OEI CSB-MP708955OEI CSB-EP708955OEI-B	Recombinant Oncorhynchus mykiss Myeloid differentiation primary response protein MyD88 (myd88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP730396DIL CSB-EP730396DIL CSB-BP730396DIL CSB-MP730396DIL CSB-EP730396DIL-B	Recombinant Danio rerio Myeloid differentiation primary response protein MyD88 (myd88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP744333RA CSB-EP744333RA CSB-BP744333RA CSB-MP744333RA CSB-EP744333RA-B	Recombinant Rat Myeloid differentiation primary response protein MyD88 (Myd88)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MYD88 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP859945HU CSB-BP859945HU CSB-MP859945HU CSB-EP859945HU-B	Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli