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MDM2

MDM2,即鼠雙微體基因2蛋白,別名E3泛素蛋白連接酶MDM2、P53結合蛋白。它是一種由MDM2基因編碼的E3泛素連接酶,主要在細胞核質(zhì)中表達,并與多種蛋白質(zhì)的泛素化降解途徑相關。MDM2的作用機制之一是介導p53/TP53的泛素化,導致其被蛋白酶體降解,此外,MDM2還參與細胞凋亡過程,通過結合其轉錄激活域抑制p53/TP53和p73/TP73介導的細胞周期阻滯和凋亡 。MDM2在生物學上的意義非常廣泛,它不僅參與調(diào)控p53的穩(wěn)定性和生物功能,還涉及細胞周期、細胞凋亡、DNA損傷響應等多種細胞生理過程。MDM2與p53之間的相互作用形成了一個自動調(diào)節(jié)的負反饋循環(huán),對維持細胞內(nèi)環(huán)境穩(wěn)定至關重要。此外,MDM2還通過調(diào)控STAT5穩(wěn)定性來控制T細胞介導的抗腫瘤免疫,這為癌癥免疫治療提供了新的視角和潛在靶點 。

熱銷產(chǎn)品

Recombinant Mouse E3 ubiquitin-protein ligase Mdm2 (Mdm2) (CSB-EP013626MO)

驗證數(shù)據(jù)

CSB-EP013626MO

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Phospho-MDM2 (S166) Recombinant Monoclonal Antibody (CSB-RA980583A0HU)

驗證數(shù)據(jù)

CSB-RA980583A0HU

IHC image of CSB-RA980583A0HU diluted at 1:50 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.57% DAB.

CSB-RA980583A0HU

IHC image of CSB-RA980583A0HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.57% DAB.

CSB-RA980583A0HU

Immunofluorescence staining of HepG2 with CSB-RA980583A0HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 517-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA980583A0HU

Overlay Peak curve showing Hela cells stained with CSB-RA980583A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

MDM2 Antibodies

MDM2 for Homo sapiens (Human)

MDM2 Proteins

MDM2 Proteins for Mus musculus (Mouse)

MDM2 Proteins for Equus caballus (Horse)

MDM2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

MDM2 Proteins for Xenopus laevis (African clawed frog)

MDM2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

MDM2 Proteins for Mesocricetus auratus (Golden hamster)

MDM2 Proteins for Felis catus (Cat) (Felis silvestris catus)